Percutaneous absorption in experimental epidermal disease

ANNE E. SOLOMON; N. J. LOWE

doi:10.1111/j.1365-2133.1979.tb08078.x

Percutaneous absorption in experimental epidermal disease

ANNE E. SOLOMON^*, N. J. LOWE

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ ¹⁴C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease.

Original language	English (US)
Pages (from-to)	717-722
Number of pages	6
Journal	British Journal of Dermatology
Volume	100
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2133.1979.tb08078.x
State	Published - Jun 1979

ASJC Scopus subject areas

Dermatology

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10.1111/j.1365-2133.1979.tb08078.x

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abstract = "Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ 14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease.",

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AB - Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ 14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease.

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Percutaneous absorption in experimental epidermal disease

Abstract

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