Percutaneous absorption in experimental epidermal disease

ANNE E. SOLOMON*, N. J. LOWE

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Little is known about the absorption of topical drugs in epidermal disease associated with epidermal proliferation and altered keratinization. An abnormal hairless mouse epidermis was produced by three different methods: ultraviolet light irradiation, topical vitamin A acid and topical acetic acid. An increased epidermal thickness resulted and the in vitro percutaneous absorption of 0.1% (4‐ 14C) hydrocortisone was found to be increased when compared with normal hairless mouse epidermis. This is evidence for defective skin barrier function in experimental epidermal disease.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalBritish Journal of Dermatology
Volume100
Issue number6
DOIs
StatePublished - Jun 1979

ASJC Scopus subject areas

  • Dermatology

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