Percutaneous Absorption in Experimental Epidermal Proliferation

Anne E. Solomon; Nicholas J. Lowe

doi:10.1001/archderm.1978.01640190017005

Percutaneous Absorption in Experimental Epidermal Proliferation

Anne E. Solomon, Nicholas J. Lowe

Dermatology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-¹⁴C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.

Original language	English (US)
Pages (from-to)	1029-1030
Number of pages	2
Journal	Archives of Dermatology
Volume	114
Issue number	7
DOIs	https://doi.org/10.1001/archderm.1978.01640190017005
State	Published - Jul 1978

ASJC Scopus subject areas

Dermatology

Access to Document

10.1001/archderm.1978.01640190017005

Cite this

@article{24ac88e6e7c94b4e8ca4d6ee26518c7a,

title = "Percutaneous Absorption in Experimental Epidermal Proliferation",

abstract = "Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.",

author = "Solomon, {Anne E.} and Lowe, {Nicholas J.}",

year = "1978",

month = jul,

doi = "10.1001/archderm.1978.01640190017005",

language = "English (US)",

volume = "114",

pages = "1029--1030",

journal = "Archives of Dermatology",

issn = "0003-987X",

publisher = "American Medical Association",

number = "7",

}

TY - JOUR

T1 - Percutaneous Absorption in Experimental Epidermal Proliferation

AU - Solomon, Anne E.

AU - Lowe, Nicholas J.

PY - 1978/7

Y1 - 1978/7

N2 - Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.

AB - Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.

UR - http://www.scopus.com/inward/record.url?scp=0017993659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017993659&partnerID=8YFLogxK

U2 - 10.1001/archderm.1978.01640190017005

DO - 10.1001/archderm.1978.01640190017005

M3 - Article

C2 - 686720

AN - SCOPUS:0017993659

SN - 0003-987X

VL - 114

SP - 1029

EP - 1030

JO - Archives of Dermatology

JF - Archives of Dermatology

IS - 7

ER -

Percutaneous Absorption in Experimental Epidermal Proliferation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this