Percutaneous Absorption in Experimental Epidermal Proliferation

Anne E. Solomon, Nicholas J. Lowe

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Essential fatty acid deficiency (EFAD) results in epidermal hyperproliferation with acanthosis and hyperkeratosis. The EFAD hairless mouse has been used to study the percutaneous absorption of a 0.1% solution of 4-14C-hydrocortisone. In vitro absorption was increased significantly through EFAD compared with normal hairless mouse skin. This is further evidence for a defective skin barrier function in epidermal hyperproliferation.

Original languageEnglish (US)
Pages (from-to)1029-1030
Number of pages2
JournalArchives of dermatology
Volume114
Issue number7
DOIs
StatePublished - Jul 1978

ASJC Scopus subject areas

  • Dermatology

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