Percutaneous or surgical revascularization is associated with survival benefit in stable coronary artery disease

Robert J.H. Miller, Robert O. Bonow, Heidi Gransar, Rebekah Park, Piotr J. Slomka, John D. Friedman, Sean Hayes, Louise Thomson, Balaji Tamarappoo, Alan Rozanski, Torsten Doenst, Daniel S. Berman

Research output: Contribution to journalArticle

Abstract

AIMS : We assessed the association between early invasive therapy, burden of ischaemia, and survival benefit separately for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Ischaemia involving more than 10% of the left ventricular myocardium may identify patients who benefit from revascularization. However, it is not clear whether this association exists with both PCI and CABG. MATERIALS AND RESULTS: Patients who underwent single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) between 1992 and 2012 were identified. Early revascularization was defined as PCI or CABG performed within 90 days of SPECT MPI. The association between early PCI or CABG and all-cause mortality was assessed using a doubly robust, propensity score matching analysis. In total, 54 522 patients were identified, with median follow-up 8.0 years. Early PCI was performed in 2688 patients and early CABG in 1228. In the matched cohorts, early revascularization was associated with improved survival compared to medical therapy in patients with more than 15% ischaemia for both PCI [adjusted hazard ratio (HR) 0.70, P = 0.002] and CABG (adjusted HR 0.73, P = 0.008). CONCLUSION : In this observational analysis, both PCI and CABG were associated with reduced all-cause mortality in the presence of moderate to severe ischaemia after adjusting for factors leading to revascularization. As the threshold for improved outcomes with revascularization was similar for PCI and CABG, our results suggest that decisions for PCI vs. CABG for early revascularization should be determined by coronary anatomy, patient characteristics, and shared decision making, but not by the burden of ischaemia.

Original languageEnglish (US)
Pages (from-to)961-970
Number of pages10
JournalEuropean heart journal cardiovascular Imaging
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • ischaemia
  • prognosis
  • revascularization
  • single-photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Percutaneous or surgical revascularization is associated with survival benefit in stable coronary artery disease'. Together they form a unique fingerprint.

  • Cite this

    Miller, R. J. H., Bonow, R. O., Gransar, H., Park, R., Slomka, P. J., Friedman, J. D., Hayes, S., Thomson, L., Tamarappoo, B., Rozanski, A., Doenst, T., & Berman, D. S. (2020). Percutaneous or surgical revascularization is associated with survival benefit in stable coronary artery disease. European heart journal cardiovascular Imaging, 21(9), 961-970. https://doi.org/10.1093/ehjci/jeaa083