Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex

Lissa B. Padnick, R. A. Linsenmeier*, Thomas K. Goldstick

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Tissue PO2 was measured in the primary visual cortex of anesthetized, artificially ventilated, normovolemic cats to evaluate the effect of small doses [1 g perfluorocarbon (PFC)/kg] of a PFC emulsion (1 g PFC/1.1 ml emulsion Alliance Pharmaceutical, San Diego, CA) on brain oxygenation. The change in tissue PO2 (ΔPO2), resulting from briefly changing the respiratory gas from room air to 100% oxygen, was measured before and after intravenous infusion of the emulsion. Before emulsion, ΔPO2 was 51.1 ± 45.6 Torr (n = 8 cats). Increases in ΔPO2 of 34.0 ± 26.1 (SD) % (n = 8) and 16.3 ± 8.4% (n = 6) were observed after the first and second emulsion infusions, respectively. The further increase in ΔPO2 after the third dose (7.9 ± 10.5% n = 7) was not statistically significant. The observed increases in tissue oxygenation as a result of the PFC infusions appear to be the result of enhanced oxygen transport to the tissue.

Original languageEnglish (US)
Pages (from-to)1497-1504
Number of pages8
JournalJournal of applied physiology
Volume86
Issue number5
DOIs
StatePublished - May 1999

Keywords

  • Brain
  • Tissue oxygen tension

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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