Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis

Katherine E. McGoogan, P. Brian Smith, Steve S. Choi, Wallace Berman, Ravi Jhaveri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

We investigated the performance of aspartate aminotransferase to platelet ratio index (APRI) as a noninvasive marker of fibrosis and cirrhosis in children with chronic viral hepatitis. All of the patients 0 to 20 years old with chronic hepatitis B or C presenting at a tertiary medical center from 1992 to 2008 were identified. Thirty-six patients were evaluated with 48 biopsy results. The areas under the receiver operating characteristic curve were 0.71 for fibrosis and 0.52 for cirrhosis. When examining subgroups, the APRI performed better in older patients and in those with vertically transmitted hepatitis C virus. Further research into APRI and the other noninvasive markers of fibrosis in children with chronic viral hepatitis is warranted.

Original languageEnglish (US)
Pages (from-to)344-346
Number of pages3
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • APRI
  • Fibrosis
  • Hepatitis B
  • Hepatitis C
  • Noninvasive markers

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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