Pericyte migration from the vascular wall in response to traumatic brain injury

Paula Dore-Duffy*, Cheri Owen, Roumen Balabanov, Sharon Murphy, Thomas Beaumont, José A. Rafols

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

247 Scopus citations


Any perturbation of the blood brain barrier, whether from changes in cell physiology or from direct injury, may result in microvascular dysfunction and disease. We examined, at the ultrastructural level, microvascular pericyte responses in a well-defined model of traumatic brain injury in the rat. In areas close to the site of impact cortical pericytes underwent a number of changes within the first hour. Approximately 40% of pericytes migrated from their microvascular location. Migration occurred concomitant with a thinning of the abluminal surface of the basal lamina and an accumulation of the receptor for the urokinase plasminogen activator on the leading surface of the migrating cell. Migrated pericytes appeared viable and remained in a perivascular location in the adjacent neuropil. Nonmigrating pericytes in the same section displayed cytoplasmic alterations and nuclear chromatin changes consistent with a rapid degenerative process. (C) 2000 Academic Press.

Original languageEnglish (US)
Article number92244
Pages (from-to)55-69
Number of pages15
JournalMicrovascular Research
Issue number1
StatePublished - 2000


  • Apoptosis
  • Endothelial cell
  • Microvessels
  • Migration
  • Pericyte
  • Traumatic brain injury
  • Urokinase plasminogen activator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Biochemistry
  • Cell Biology


Dive into the research topics of 'Pericyte migration from the vascular wall in response to traumatic brain injury'. Together they form a unique fingerprint.

Cite this