Perientric inversion (2)(p15q35) in an alveolar rhabdomyosarcoma

Jeffrey R. Sawyer*, Frank G. Crussi, Morris Kletzel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We report a 7-year-old girl with a pericentric inversion of chromosome 2, inv(2)(p15q35), in a "solid variant" of alveolar rhabdomyosarcoma. The breakpoint in the long arm of chromosome 2 at band q35 is, at the cytogenetic level, identical to the breakpoint observed in the well-established reciprocal t(2;13)(q35;q14) associated with the alveolar subtype of rhabdomyosarcoma. In this case, however, no reciprocal translocation has occurred with chromosome 13 or any other chromosome, suggesting that the single critical breakpoint in alveolar rhabdomyosarcoma may be located at 2q35.

Original languageEnglish (US)
Pages (from-to)214-218
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume78
Issue number2
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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