Perinucleolar compartment and transformation

K. Kopp, S. Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

The perinucleolar compartment (PNC) is a sub-nuclear structure that preferentially localizes to the nucleolar periphery. The PNC is found predominantly in transformed cells both in vitro and in vivo. PNC prevalence (the percentage of cells containing at least one PNC) positively correlates with the progression of breast cancer and patient survival. PNCs are highly enriched with newly synthesized RNA polymerase III transcripts and RNA-binding proteins. The structural integrity of the PNC is dependent upon the transcription of these RNAs and a critical level of the polypyrimidine tract binding (PTB) protein, as assayed by the localization of other PNC-associated proteins. These observations suggest a model in which the PNC is a dynamic, functional organelle that forms under specific physiological conditions favoring cellular transformation and might be involved in the metabolism of RNA polymerase III transcripts.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalJournal of Cellular Biochemistry
Volume95
Issue number2
DOIs
StatePublished - May 15 2005

Keywords

  • Nuclear sub-structure
  • Perinucleolar compartment (PNC)
  • RNA metabolism
  • Transformation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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