Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy: A prospective, multicenter experience

Sarah Tabbutt*, Susan C. Nicolson, Troy E. Dominguez, Winfield Wells, Carl L Backer, James S. Tweddell, Paula Bokesch, Mark Schreiner

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The hospital course for pediatric coarctation repair has not been described. We had 4 aims: (1) to determine the influence of age, anatomy, and type of repair on aortic crossclamp time, (2) to determine the impact of age or aortic crossclamp time on postoperative morbidity, (3) to describe current antihypertensive strategies, and (4) to describe antihypertensive medications at hospital discharge. Methods: Data were obtained from a prospective randomized multicenter esmolol safety and efficacy trial. The study included patients who were scheduled for a coarctation repair receiving esmolol as their first-line antihypertensive medication in the operating room (n = 118; weight ≥ 2.5 kg and age < 6 years). Results: (1) Patient age and type of coarctation did not affect the aortic crossclamp time. (2) Younger age, but not aortic crossclamp time, was associated with a significantly longer time to extubation and longer hospital length of stay. (3) A combination of esmolol and sodium nitroprusside (Nipride, Roche, Basel, Switzerland) provided excellent early blood pressure control. (4) At discharge, 64% of patients were receiving antihypertensive medications. Older patients were more likely to be discharged with antihypertensive medication (91% of patients aged 2-6 years, P < .0002). Conclusion: The study describes a multi-institutional approach to the repair of isolated coarctation in infants and children. Patients repaired by end-to-end anastomosis had shorter aortic crossclamp time, younger patients had longer hospital length of stay, a majority of patients had sodium nitroprusside (Nipride) added to esmolol for early blood pressure control, and older patients were more likely to be discharged with antihypertensive medication.

Original languageEnglish (US)
Pages (from-to)1229-1236
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume136
Issue number5
DOIs
StatePublished - Nov 1 2008

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Thoracotomy
Antihypertensive Agents
Length of Stay
Nitroprusside
Blood Pressure
Pediatric Hospitals
Patient Discharge
Operating Rooms
Switzerland
Anatomy
Morbidity
Safety
Weights and Measures
esmolol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Tabbutt, Sarah ; Nicolson, Susan C. ; Dominguez, Troy E. ; Wells, Winfield ; Backer, Carl L ; Tweddell, James S. ; Bokesch, Paula ; Schreiner, Mark. / Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy : A prospective, multicenter experience. In: Journal of Thoracic and Cardiovascular Surgery. 2008 ; Vol. 136, No. 5. pp. 1229-1236.
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title = "Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy: A prospective, multicenter experience",
abstract = "Objective: The hospital course for pediatric coarctation repair has not been described. We had 4 aims: (1) to determine the influence of age, anatomy, and type of repair on aortic crossclamp time, (2) to determine the impact of age or aortic crossclamp time on postoperative morbidity, (3) to describe current antihypertensive strategies, and (4) to describe antihypertensive medications at hospital discharge. Methods: Data were obtained from a prospective randomized multicenter esmolol safety and efficacy trial. The study included patients who were scheduled for a coarctation repair receiving esmolol as their first-line antihypertensive medication in the operating room (n = 118; weight ≥ 2.5 kg and age < 6 years). Results: (1) Patient age and type of coarctation did not affect the aortic crossclamp time. (2) Younger age, but not aortic crossclamp time, was associated with a significantly longer time to extubation and longer hospital length of stay. (3) A combination of esmolol and sodium nitroprusside (Nipride, Roche, Basel, Switzerland) provided excellent early blood pressure control. (4) At discharge, 64{\%} of patients were receiving antihypertensive medications. Older patients were more likely to be discharged with antihypertensive medication (91{\%} of patients aged 2-6 years, P < .0002). Conclusion: The study describes a multi-institutional approach to the repair of isolated coarctation in infants and children. Patients repaired by end-to-end anastomosis had shorter aortic crossclamp time, younger patients had longer hospital length of stay, a majority of patients had sodium nitroprusside (Nipride) added to esmolol for early blood pressure control, and older patients were more likely to be discharged with antihypertensive medication.",
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Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy : A prospective, multicenter experience. / Tabbutt, Sarah; Nicolson, Susan C.; Dominguez, Troy E.; Wells, Winfield; Backer, Carl L; Tweddell, James S.; Bokesch, Paula; Schreiner, Mark.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 136, No. 5, 01.11.2008, p. 1229-1236.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perioperative course in 118 infants and children undergoing coarctation repair via a thoracotomy

T2 - A prospective, multicenter experience

AU - Tabbutt, Sarah

AU - Nicolson, Susan C.

AU - Dominguez, Troy E.

AU - Wells, Winfield

AU - Backer, Carl L

AU - Tweddell, James S.

AU - Bokesch, Paula

AU - Schreiner, Mark

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Objective: The hospital course for pediatric coarctation repair has not been described. We had 4 aims: (1) to determine the influence of age, anatomy, and type of repair on aortic crossclamp time, (2) to determine the impact of age or aortic crossclamp time on postoperative morbidity, (3) to describe current antihypertensive strategies, and (4) to describe antihypertensive medications at hospital discharge. Methods: Data were obtained from a prospective randomized multicenter esmolol safety and efficacy trial. The study included patients who were scheduled for a coarctation repair receiving esmolol as their first-line antihypertensive medication in the operating room (n = 118; weight ≥ 2.5 kg and age < 6 years). Results: (1) Patient age and type of coarctation did not affect the aortic crossclamp time. (2) Younger age, but not aortic crossclamp time, was associated with a significantly longer time to extubation and longer hospital length of stay. (3) A combination of esmolol and sodium nitroprusside (Nipride, Roche, Basel, Switzerland) provided excellent early blood pressure control. (4) At discharge, 64% of patients were receiving antihypertensive medications. Older patients were more likely to be discharged with antihypertensive medication (91% of patients aged 2-6 years, P < .0002). Conclusion: The study describes a multi-institutional approach to the repair of isolated coarctation in infants and children. Patients repaired by end-to-end anastomosis had shorter aortic crossclamp time, younger patients had longer hospital length of stay, a majority of patients had sodium nitroprusside (Nipride) added to esmolol for early blood pressure control, and older patients were more likely to be discharged with antihypertensive medication.

AB - Objective: The hospital course for pediatric coarctation repair has not been described. We had 4 aims: (1) to determine the influence of age, anatomy, and type of repair on aortic crossclamp time, (2) to determine the impact of age or aortic crossclamp time on postoperative morbidity, (3) to describe current antihypertensive strategies, and (4) to describe antihypertensive medications at hospital discharge. Methods: Data were obtained from a prospective randomized multicenter esmolol safety and efficacy trial. The study included patients who were scheduled for a coarctation repair receiving esmolol as their first-line antihypertensive medication in the operating room (n = 118; weight ≥ 2.5 kg and age < 6 years). Results: (1) Patient age and type of coarctation did not affect the aortic crossclamp time. (2) Younger age, but not aortic crossclamp time, was associated with a significantly longer time to extubation and longer hospital length of stay. (3) A combination of esmolol and sodium nitroprusside (Nipride, Roche, Basel, Switzerland) provided excellent early blood pressure control. (4) At discharge, 64% of patients were receiving antihypertensive medications. Older patients were more likely to be discharged with antihypertensive medication (91% of patients aged 2-6 years, P < .0002). Conclusion: The study describes a multi-institutional approach to the repair of isolated coarctation in infants and children. Patients repaired by end-to-end anastomosis had shorter aortic crossclamp time, younger patients had longer hospital length of stay, a majority of patients had sodium nitroprusside (Nipride) added to esmolol for early blood pressure control, and older patients were more likely to be discharged with antihypertensive medication.

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