Perioperative Strategies and Thrombophilia in Children with Extrahepatic Portal Vein Obstruction Undergoing the Meso-Rex Bypass

Rukhmi Bhat*, Timothy B Lautz, Riccardo A Superina, Robert I Liem

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Background/Purpose: Extrahepatic portal vein obstruction (EHPVO) is an important cause of chronic portal hypertension in children. Although usually idiopathic in etiology, genetic and acquired thrombophilia have been implicated in EHPVO. Meso-Rex bypass is increasingly used to treat EHPVO in children. Objective: The objective of this study is to assess the relationship of postoperative anticoagulation strategies and thrombophilic risk factors to the development of bypass thrombosis following the meso-Rex bypass. Methods: Records of children who underwent meso-Rex bypass for EHPVO at a single institution from 1999 to 2009 were reviewed, and preoperative thrombophilia testing, perioperative anticoagulation strategies, and postoperative bypass patency based on imaging at last follow-up were examined. Results: Sixty-five children with EHPVO underwent a first time meso-Rex bypass during the study period, and 9 of 65 (14 %) developed bypass thrombosis. The use of warfarin in the postoperative period was more common among children with thrombosed shunts than among those with open shunts [63 % vs. 20 %; OR, 6. 5 (95 % CI, 1. 3-31. 5), p = 0. 022]. The contribution of genetic or acquired thrombophilia to shunt thrombosis was inconclusive given variability in testing. Conclusions: Choice of anticoagulation following meso-Rex bypass may affect postoperative incidence of bypass thrombosis. Role of thrombophilic risk factors in the development of shunt thrombosis remains unclear.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume17
Issue number5
DOIs
StatePublished - Feb 11 2013

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Keywords

  • Anticoagulation
  • Extrahepatic portal vein obstruction
  • Meso-Rex bypass
  • Thrombophilia
  • Thrombosis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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