Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker

Rebecca Reindel, Kwang Youn A. Kim, Susan C. Baker, Stanford T. Shulman, Elizabeth J. Perlman, Mark W. Lingen, Cynthia Trevenen, Anne H. Rowley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Periostin was upregulated 11-fold in acute and chronic Kawasaki Disease coronary arteries compared with controls (P = 0.003). Kawasaki Disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.

Original languageEnglish (US)
Pages (from-to)659-661
Number of pages3
JournalPediatric Infectious Disease Journal
Volume33
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Kawasaki disease
  • biomarker
  • periostin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker'. Together they form a unique fingerprint.

Cite this