Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker

Rebecca Reindel; Kwang Youn A. Kim; Susan C. Baker; Stanford T. Shulman; Elizabeth J. Perlman; Mark W. Lingen; Cynthia Trevenen; Anne H. Rowley

doi:10.1097/INF.0000000000000233

Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker

Rebecca Reindel, Kwang Youn A. Kim, Susan C. Baker, Stanford T. Shulman, Elizabeth J. Perlman, Mark W. Lingen, Cynthia Trevenen, Anne H. Rowley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Periostin was upregulated 11-fold in acute and chronic Kawasaki Disease coronary arteries compared with controls (P = 0.003). Kawasaki Disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.

Original language	English (US)
Pages (from-to)	659-661
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	6
DOIs	https://doi.org/10.1097/INF.0000000000000233
State	Published - Jun 2014

Keywords

Kawasaki disease
biomarker
periostin

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000000233

Cite this

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title = "Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker",

abstract = "Periostin was upregulated 11-fold in acute and chronic Kawasaki Disease coronary arteries compared with controls (P = 0.003). Kawasaki Disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.",

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T1 - Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker

AU - Reindel, Rebecca

AU - Kim, Kwang Youn A.

AU - Baker, Susan C.

AU - Shulman, Stanford T.

AU - Perlman, Elizabeth J.

AU - Lingen, Mark W.

AU - Trevenen, Cynthia

AU - Rowley, Anne H.

PY - 2014/6

Y1 - 2014/6

N2 - Periostin was upregulated 11-fold in acute and chronic Kawasaki Disease coronary arteries compared with controls (P = 0.003). Kawasaki Disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.

AB - Periostin was upregulated 11-fold in acute and chronic Kawasaki Disease coronary arteries compared with controls (P = 0.003). Kawasaki Disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.

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KW - biomarker

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Periostin is upregulated in coronary arteriopathy in Kawasaki Disease and is a potential diagnostic biomarker

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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