Peripheral and central viewpoints of chronic pain, and translational implications

A. Vania Apkarian*, Diane Reckziegel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalNeuroscience Letters
Volume702
DOIs
StatePublished - May 29 2019

Funding

The authors acknowledge support by National Institute of Dental and Craniofacial Research ( 5R01DE022746-02 ), National Center for Complementary and Integrative Health ( AT007987 ) and National Institute on Drug Abuse ( 1P50DA044121-01A1 ).

Keywords

  • Brain imaging
  • Chronic pain
  • Limbic system
  • Sensory testing
  • Spinal cord

ASJC Scopus subject areas

  • General Neuroscience

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