Peripheral and central viewpoints of chronic pain, and translational implications

A. Vania Apkarian; Diane Reckziegel

doi:10.1016/j.neulet.2018.11.040

Peripheral and central viewpoints of chronic pain, and translational implications

A. Vania Apkarian^*, Diane Reckziegel

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.

Original language	English (US)
Pages (from-to)	3-5
Number of pages	3
Journal	Neuroscience Letters
Volume	702
DOIs	https://doi.org/10.1016/j.neulet.2018.11.040
State	Published - May 29 2019

Funding

The authors acknowledge support by National Institute of Dental and Craniofacial Research ( 5R01DE022746-02 ), National Center for Complementary and Integrative Health ( AT007987 ) and National Institute on Drug Abuse ( 1P50DA044121-01A1 ).

Keywords

Brain imaging
Chronic pain
Limbic system
Sensory testing
Spinal cord

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2018.11.040

Cite this

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abstract = "This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.",

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AU - Reckziegel, Diane

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N2 - This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.

AB - This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.

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KW - Chronic pain

KW - Limbic system

KW - Sensory testing

KW - Spinal cord

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JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

Peripheral and central viewpoints of chronic pain, and translational implications

Abstract

Funding

Keywords

ASJC Scopus subject areas

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