Peripheral and central viewpoints of chronic pain, and translational implications

A. Vania Apkarian*, Diane Reckziegel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


This overview covers advances in mechanisms of chronic pain and their consequent clinical opportunities. Our research field is fractured into two separate camps: “peripheralists” and “centralists”. While the strong position of the first group is the contention that mechanisms of chronic pain can be understood within the limits of afferent inputs and spinal cord circuitry, the second group insists that the rest of the brain plays a critical role. Here we attempt to conjoin these positions, across clinical pain conditions and animal studies, and demonstrate that the effort can lead to novel translational concepts.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalNeuroscience Letters
StatePublished - May 29 2019


  • Brain imaging
  • Chronic pain
  • Limbic system
  • Sensory testing
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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