Peripheral artery disease: Epidemiology and global perspectives

F. Gerry R. Fowkes*, Victor Aboyans, Freya J.I. Fowkes, Mary M. McDermott, Uchechukwu K.A. Sampson, Michael H. Criqui

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

422 Scopus citations


Global populations are undergoing a major epidemiological transition in which the burden of atherosclerotic cardiovascular diseases is shifting rapidly from high-income to low-income and middle-income countries (LMICs). Peripheral artery disease (PAD) is no exception, so that greater focus is now required on the prevention and management of this disease in less-advantaged countries. In this Review, we examine the epidemiology of PAD and, where feasible, take a global perspective. However, the dearth of publications in LMICs means an unavoidable over-reliance on studies in high-income countries. Research to date suggests that PAD might affect a greater proportion of women than men in LMICs. Although factors such as poverty, industrialization, and infection might conceivably influence the development of PAD in such settings, the ageing of the population and increase in traditional cardiovascular risk factors, such as smoking, diabetes mellitus, and hypertension, are likely to be the main driving forces.

Original languageEnglish (US)
Pages (from-to)156-170
Number of pages15
JournalNature Reviews Cardiology
Issue number3
StatePublished - Mar 1 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Peripheral artery disease: Epidemiology and global perspectives'. Together they form a unique fingerprint.

Cite this