Peripheral Gangrene Associated with Kawasaki Disease

Shobun Tomita, Kyung Chung, Madeline Mas, Samuel Gidding, Stanford T. Shulman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Three American infants with Kawasaki disease (KD) complicated by peripheral extremity gangrene are reported. Eight such patients (only 1 from Japan) have been reported previously. These 11 patients, infants <7 months old at onset of KD, are predominantly non-Asian. At least nine had associated giant coronary aneurysms, and eight had associated peripheral arterial aneurysms. In eight infants the diagnosis of KD was not established and therapy was not instituted until?14 days after onset. Peripheral ischemia initially was noted 15-31 days after onset. Although the pathogenesis of this complication is not well understood, it likely includes some combination of local peripheral arteritis, arteriospasm, thrombosis peripherally and/or more proximally (e.g., in an axillary artery aneurysm), and cardiogenic shock. Treatment may include use of antiinflammatory agents such as salicylates and intravenous gamma globulin, vasodilative agents and/or methods, and thrombolytic and/or anticoagulant agents in an attempt to prevent the potentially devastating consequences of progressive gangrene.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalClinical Infectious Diseases
Issue number1
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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