Peripheral mechanisms of itch

Benjamin McNeil, Xinzhong Dong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Detection of environmental stimuli that provoke an aversive response has been shown to involve many receptors in the periphery. Probably the least-studied of these stimuli are those that induce the perception of itch (pruritus), an often-experienced unpleasant stimulus. This review covers the ligands and their receptors which are known to cause primary sensory neuron activation and initiate itch sensation. Also covered are several itch-inducing substances which may act indirectly by activating other cell types in the periphery which then signal to primary neurons. Finally, progress in identifying candidate neurotransmitters that sensory neurons use to propagate the itch signal is discussed.

Original languageEnglish (US)
Pages (from-to)100-110
Number of pages11
JournalNeuroscience Bulletin
Volume28
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • Itch
  • Primary sensory neurons
  • Receptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint

Dive into the research topics of 'Peripheral mechanisms of itch'. Together they form a unique fingerprint.

Cite this