Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kimberly A. Carlson, Santhi Gorantla, Chad Branecki, Shrinivas Bishu, Huangui Xiong, Howard E. Gendelman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)112-129
Number of pages18
JournalJournal of Neuroimmunology
Volume142
Issue number1-2
DOIs
StatePublished - Sep 2003

Funding

The authors extend a special thanks to Ms. Robin Taylor for outstanding administrative and computer support and Dr. Michal Schwartz for lively discussions. This work was supported in part by NIH grants 2R37 NS 3613, PO1 NS 31492, 2R01 NS3423 and P01 MH050244.

Keywords

  • Monocyte-derived macrophages
  • Neurotrophins
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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