Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata; Marina Zelivyanskaya; Jenae Limoges; Kimberly A. Carlson; Santhi Gorantla; Chad Branecki; Shrinivas Bishu; Huangui Xiong; Howard E. Gendelman

doi:10.1016/S0165-5728(03)00253-4

Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kimberly A. Carlson, Santhi Gorantla, Chad Branecki, Shrinivas Bishu, Huangui Xiong, Howard E. Gendelman^*

^*Corresponding author for this work

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Abstract

Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original language	English (US)
Pages (from-to)	112-129
Number of pages	18
Journal	Journal of Neuroimmunology
Volume	142
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(03)00253-4
State	Published - Sep 2003

Funding

The authors extend a special thanks to Ms. Robin Taylor for outstanding administrative and computer support and Dr. Michal Schwartz for lively discussions. This work was supported in part by NIH grants 2R37 NS 3613, PO1 NS 31492, 2R01 NS3423 and P01 MH050244.

Keywords

Monocyte-derived macrophages
Neurotrophins
Signal transduction

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(03)00253-4

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Shibata, A., Zelivyanskaya, M., Limoges, J., Carlson, K. A., Gorantla, S., Branecki, C., Bishu, S., Xiong, H., & Gendelman, H. E. (2003). Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. Journal of Neuroimmunology, 142(1-2), 112-129. https://doi.org/10.1016/S0165-5728(03)00253-4

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title = "Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function",

abstract = "Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.",

keywords = "Monocyte-derived macrophages, Neurotrophins, Signal transduction",

author = "Annemarie Shibata and Marina Zelivyanskaya and Jenae Limoges and Carlson, {Kimberly A.} and Santhi Gorantla and Chad Branecki and Shrinivas Bishu and Huangui Xiong and Gendelman, {Howard E.}",

note = "Funding Information: The authors extend a special thanks to Ms. Robin Taylor for outstanding administrative and computer support and Dr. Michal Schwartz for lively discussions. This work was supported in part by NIH grants 2R37 NS 3613, PO1 NS 31492, 2R01 NS3423 and P01 MH050244. ",

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doi = "10.1016/S0165-5728(03)00253-4",

language = "English (US)",

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Shibata, A, Zelivyanskaya, M, Limoges, J, Carlson, KA, Gorantla, S, Branecki, C, Bishu, S, Xiong, H & Gendelman, HE 2003, 'Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function', Journal of Neuroimmunology, vol. 142, no. 1-2, pp. 112-129. https://doi.org/10.1016/S0165-5728(03)00253-4

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T1 - Peripheral nerve induces macrophage neurotrophic activities

T2 - Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

AU - Shibata, Annemarie

AU - Zelivyanskaya, Marina

AU - Limoges, Jenae

AU - Carlson, Kimberly A.

AU - Gorantla, Santhi

AU - Branecki, Chad

AU - Bishu, Shrinivas

AU - Xiong, Huangui

AU - Gendelman, Howard E.

N1 - Funding Information: The authors extend a special thanks to Ms. Robin Taylor for outstanding administrative and computer support and Dr. Michal Schwartz for lively discussions. This work was supported in part by NIH grants 2R37 NS 3613, PO1 NS 31492, 2R01 NS3423 and P01 MH050244.

PY - 2003/9

Y1 - 2003/9

N2 - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

AB - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

KW - Monocyte-derived macrophages

KW - Neurotrophins

KW - Signal transduction

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Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Abstract

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Keywords

ASJC Scopus subject areas

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