Abstract
Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.
Original language | English (US) |
---|---|
Pages (from-to) | 112-129 |
Number of pages | 18 |
Journal | Journal of Neuroimmunology |
Volume | 142 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 2003 |
Funding
The authors extend a special thanks to Ms. Robin Taylor for outstanding administrative and computer support and Dr. Michal Schwartz for lively discussions. This work was supported in part by NIH grants 2R37 NS 3613, PO1 NS 31492, 2R01 NS3423 and P01 MH050244.
Keywords
- Monocyte-derived macrophages
- Neurotrophins
- Signal transduction
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology