TY - JOUR
T1 - Peripheral nerve induces macrophage neurotrophic activities
T2 - Regulation of neuronal process outgrowth, intracellular signaling and synaptic function
AU - Shibata, Annemarie
AU - Zelivyanskaya, Marina
AU - Limoges, Jenae
AU - Carlson, Kimberly A.
AU - Gorantla, Santhi
AU - Branecki, Chad
AU - Bishu, Shrinivas
AU - Xiong, Huangui
AU - Gendelman, Howard E.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.
AB - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.
KW - Monocyte-derived macrophages
KW - Neurotrophins
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0642370977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0642370977&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(03)00253-4
DO - 10.1016/S0165-5728(03)00253-4
M3 - Article
C2 - 14512170
AN - SCOPUS:0642370977
VL - 142
SP - 112
EP - 129
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -