Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata; Marina Zelivyanskaya; Jenae Limoges; Kimberly A. Carlson; Santhi Gorantla; Chad Branecki; Shrinivas Bishu; Huangui Xiong; Howard E. Gendelman

doi:10.1016/S0165-5728(03)00253-4

Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kimberly A. Carlson, Santhi Gorantla, Chad Branecki, Shrinivas Bishu, Huangui Xiong, Howard E. Gendelman^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original language	English (US)
Pages (from-to)	112-129
Number of pages	18
Journal	Journal of Neuroimmunology
Volume	142
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(03)00253-4
State	Published - Sep 1 2003

Keywords

Monocyte-derived macrophages
Neurotrophins
Signal transduction

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Shibata, A., Zelivyanskaya, M., Limoges, J., Carlson, K. A., Gorantla, S., Branecki, C., Bishu, S., Xiong, H., & Gendelman, H. E. (2003). Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. Journal of Neuroimmunology, 142(1-2), 112-129. https://doi.org/10.1016/S0165-5728(03)00253-4

Shibata, Annemarie ; Zelivyanskaya, Marina ; Limoges, Jenae ; Carlson, Kimberly A. ; Gorantla, Santhi ; Branecki, Chad ; Bishu, Shrinivas ; Xiong, Huangui ; Gendelman, Howard E. / Peripheral nerve induces macrophage neurotrophic activities : Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. In: Journal of Neuroimmunology. 2003 ; Vol. 142, No. 1-2. pp. 112-129.

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abstract = "Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.",

keywords = "Monocyte-derived macrophages, Neurotrophins, Signal transduction",

author = "Annemarie Shibata and Marina Zelivyanskaya and Jenae Limoges and Carlson, {Kimberly A.} and Santhi Gorantla and Chad Branecki and Shrinivas Bishu and Huangui Xiong and Gendelman, {Howard E.}",

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Shibata, A, Zelivyanskaya, M, Limoges, J, Carlson, KA, Gorantla, S, Branecki, C, Bishu, S, Xiong, H & Gendelman, HE 2003, 'Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function', Journal of Neuroimmunology, vol. 142, no. 1-2, pp. 112-129. https://doi.org/10.1016/S0165-5728(03)00253-4

Peripheral nerve induces macrophage neurotrophic activities : Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. / Shibata, Annemarie; Zelivyanskaya, Marina; Limoges, Jenae; Carlson, Kimberly A.; Gorantla, Santhi; Branecki, Chad; Bishu, Shrinivas; Xiong, Huangui; Gendelman, Howard E.

In: Journal of Neuroimmunology, Vol. 142, No. 1-2, 01.09.2003, p. 112-129.

Research output: Contribution to journal › Article › peer-review

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T2 - Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

AU - Shibata, Annemarie

AU - Zelivyanskaya, Marina

AU - Limoges, Jenae

AU - Carlson, Kimberly A.

AU - Gorantla, Santhi

AU - Branecki, Chad

AU - Bishu, Shrinivas

AU - Xiong, Huangui

AU - Gendelman, Howard E.

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