Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kimberly A. Carlson, Santhi Gorantla, Chad Branecki, Shrinivas Bishu, Huangui Xiong, Howard E. Gendelman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)112-129
Number of pages18
JournalJournal of Neuroimmunology
Volume142
Issue number1-2
DOIs
StatePublished - Sep 1 2003

Keywords

  • Monocyte-derived macrophages
  • Neurotrophins
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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