Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit

Chen Zheng, Paul Feinstein, Thomas Bozza, Ivan Rodriguez, Peter Mombaerts*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

Axons of olfactory sensory neurons expressing a given odorant receptor converge to a few glomeruli in the olfactory bulb. We have generated mice with unresponsive olfactory sensory neurons by targeted mutagenesis of a cyclic nucleotide-gated channel subunit gene, OCNC1. When these anosmic mice were crossed with mice in which neurons expressing a given odorant receptor can be visualized by coexpression of an axonal marker, the pattern of convergence was affected for one but not another receptor. In a novel paradigm, termed monoallelic deprivation, axons from channel positive or negative neurons that express the same odorant receptor segregate into distinct glomeruli within the same bulb. Thus, the peripheral olfactory projections are in part influenced by mechanisms that depend on neuronal activity.

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalNeuron
Volume26
Issue number1
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)

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