Abstract
Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.
Original language | English (US) |
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Pages (from-to) | 255-264 |
Number of pages | 10 |
Journal | Biomarkers in Medicine |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2016 |
Keywords
- aggressiveness
- biomarker
- cerebral cavernous malformation
- inflammation
- non-HDL cholesterol
- vitamin D
ASJC Scopus subject areas
- Drug Discovery
- Clinical Biochemistry
- Biochemistry, medical