Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

Romuald Girard; Omaditya Khanna; Robert Shenkar; Lingjiao Zhang; Meijing Wu; Michael Jesselson; Hussein A. Zeineddine; Anupriya Gangal; Maged D. Fam; Christopher C. Gibson; Kevin J. Whitehead; Dean Y. Li; James K. Liao; Changbin Shi; Issam A. Awad

doi:10.2217/bmm.15.118

Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

Romuald Girard, Omaditya Khanna, Robert Shenkar, Lingjiao Zhang, Meijing Wu, Michael Jesselson, Hussein A. Zeineddine, Anupriya Gangal, Maged D. Fam, Christopher C. Gibson, Kevin J. Whitehead, Dean Y. Li, James K. Liao, Changbin Shi, Issam A. Awad^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

Original language	English (US)
Pages (from-to)	255-264
Number of pages	10
Journal	Biomarkers in Medicine
Volume	10
Issue number	3
DOIs	https://doi.org/10.2217/bmm.15.118
State	Published - Mar 2016

Keywords

aggressiveness
biomarker
cerebral cavernous malformation
inflammation
non-HDL cholesterol
vitamin D

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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Girard, R., Khanna, O., Shenkar, R., Zhang, L., Wu, M., Jesselson, M., Zeineddine, H. A., Gangal, A., Fam, M. D., Gibson, C. C., Whitehead, K. J., Li, D. Y., Liao, J. K., Shi, C., & Awad, I. A. (2016). Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease. Biomarkers in Medicine, 10(3), 255-264. https://doi.org/10.2217/bmm.15.118

@article{b195d5ed6b8a4a789b6df3cd638b7427,

title = "Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease",

abstract = "Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.",

keywords = "aggressiveness, biomarker, cerebral cavernous malformation, inflammation, non-HDL cholesterol, vitamin D",

author = "Romuald Girard and Omaditya Khanna and Robert Shenkar and Lingjiao Zhang and Meijing Wu and Michael Jesselson and Zeineddine, {Hussein A.} and Anupriya Gangal and Fam, {Maged D.} and Gibson, {Christopher C.} and Whitehead, {Kevin J.} and Li, {Dean Y.} and Liao, {James K.} and Changbin Shi and Awad, {Issam A.}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = mar,

doi = "10.2217/bmm.15.118",

language = "English (US)",

volume = "10",

pages = "255--264",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "3",

}

Girard, R, Khanna, O, Shenkar, R, Zhang, L, Wu, M, Jesselson, M, Zeineddine, HA, Gangal, A, Fam, MD, Gibson, CC, Whitehead, KJ, Li, DY, Liao, JK, Shi, C & Awad, IA 2016, 'Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease', Biomarkers in Medicine, vol. 10, no. 3, pp. 255-264. https://doi.org/10.2217/bmm.15.118

TY - JOUR

T1 - Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

AU - Girard, Romuald

AU - Khanna, Omaditya

AU - Shenkar, Robert

AU - Zhang, Lingjiao

AU - Wu, Meijing

AU - Jesselson, Michael

AU - Zeineddine, Hussein A.

AU - Gangal, Anupriya

AU - Fam, Maged D.

AU - Gibson, Christopher C.

AU - Whitehead, Kevin J.

AU - Li, Dean Y.

AU - Liao, James K.

AU - Shi, Changbin

AU - Awad, Issam A.

PY - 2016/3

Y1 - 2016/3

N2 - Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

AB - Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

KW - aggressiveness

KW - biomarker

KW - cerebral cavernous malformation

KW - inflammation

KW - non-HDL cholesterol

KW - vitamin D

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JF - Biomarkers in Medicine

SN - 1752-0363

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Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

Abstract

Keywords

ASJC Scopus subject areas

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