Peripheral plasma Vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

Romuald Girard, Omaditya Khanna, Robert Shenkar, Lingjiao Zhang, Meijing Wu, Michael Jesselson, Hussein A. Zeineddine, Anupriya Gangal, Maged D. Fam, Christopher C. Gibson, Kevin J. Whitehead, Dean Y. Li, James K. Liao, Changbin Shi, Issam A. Awad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

Original languageEnglish (US)
Pages (from-to)255-264
Number of pages10
JournalBiomarkers in Medicine
Volume10
Issue number3
DOIs
StatePublished - Mar 2016

Keywords

  • aggressiveness
  • biomarker
  • cerebral cavernous malformation
  • inflammation
  • non-HDL cholesterol
  • vitamin D

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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