Peripheral proliferative retinopathies: An update on angiogenesis, etiologies and management

Lee Merrill Jampol*, Daniel A. Ebroon, Michael H. Goldbaum

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Many clinical entities may be associated with the development of peripheral retinal neovascularization. In this paper, we review the mechanisms of normal and abnormal angiogenesis in the retina. Specific disease entities associated with peripheral proliferative retinopathies are discussed. These include vascular disease with ischemia, inflammatory diseases with possible ischemia and a variety of miscellaneous causes, including hereditary diseases and tumors. Basic principles for the clinical evaluation of patients with retinal neovascularization are described. Finally, the treatments for retinal neovascularization, including cryopexy and local and panretinal photocoagulation are reviewed, and techniques and possible mechanisms of the beneficial results of treatment are described.

Original languageEnglish (US)
Pages (from-to)519-540
Number of pages22
JournalSurvey of ophthalmology
Issue number6
StatePublished - Jan 1 1994


  • angiogenesis
  • cryopexy
  • diabetes
  • inflammatory disease
  • neovasculariration
  • panretinal photocoagulation
  • proliferative retinopathies
  • retina
  • vascular disease

ASJC Scopus subject areas

  • Ophthalmology


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