TY - JOUR
T1 - Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). A new prognostic model developed by the International T cell Project Network
AU - the T cell Project Network
AU - Federico, Massimo
AU - Bellei, Monica
AU - Marcheselli, Luigi
AU - Schwartz, Marc
AU - Manni, Martina
AU - Tarantino, Vittoria
AU - Pileri, Stefano
AU - Ko, Young Hyeh
AU - Cabrera, Maria E.
AU - Horwitz, Steven
AU - Kim, Won S.
AU - Shustov, Andrei
AU - Foss, Francine M.
AU - Nagler, Arnon
AU - Carson, Kenneth
AU - Pinter-Brown, Lauren C.
AU - Montoto, Silvia
AU - Spina, Michele
AU - Feldman, Tatyana A.
AU - Lechowicz, Mary J.
AU - Smith, Sonali M.
AU - Lansigan, Frederick
AU - Gabus, Raul
AU - Vose, Julie M.
AU - Advani, Ranjana H.
N1 - Funding Information:
This work was supported by a grant from: Fondazione Cassa di Risparmio di Modena, Associazione Angela Serra per la Ricerca sul Cancro, Fondazione Italiana Linfomi, Allos Therapeutics, and Spectrum Pharmaceuticals, AIRC 5x1000 (grant n. 10007 to Stefano Pileri), the NIH/NCI CCSG P30 CA008748 (grant to Steven Horwitz). The authors wish to thank Lisa Bellm for her valuable help in the check of the patients included in both the T Cell Project and the COMPLETE Registry, a mandatory job to avoid validation of the model with cases already used for model development, and for her kindly supporting and favoring communications between the two networks.
Publisher Copyright:
© 2018 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Different models to investigate the prognosis of peripheral T cell lymphoma not otherwise specified (PTCL-NOS) have been developed by means of retrospective analyses. Here we report on a new model designed on data from the prospective T Cell Project. Twelve covariates collected by the T Cell Project were analysed and a new model (T cell score), based on four covariates (serum albumin, performance status, stage and absolute neutrophil count) that maintained their prognostic value in multiple Cox proportional hazards regression analysis was proposed. Among patients registered in the T Cell Project, 311 PTCL-NOS were retained for study. At a median follow-up of 46 months, the median overall survival (OS) and progression-free survival (PFS) was 20 and 10 months, respectively. Three groups were identified at low risk (LR, 48 patients, 15%, score 0), intermediate risk (IR, 189 patients, 61%, score 1–2), and high risk (HiR, 74 patients, 24%, score 3–4), having a 3-year OS of 76% [95% confidence interval 61–88], 43% [35–51], and 11% [4–21], respectively (P < 0·001). Comparing the performance of the T cell score on OS to that of each of the previously developed models, it emerged that the new score had the best discriminant power. The new T cell score, based on clinical variables, identifies a group with very unfavourable outcomes.
AB - Different models to investigate the prognosis of peripheral T cell lymphoma not otherwise specified (PTCL-NOS) have been developed by means of retrospective analyses. Here we report on a new model designed on data from the prospective T Cell Project. Twelve covariates collected by the T Cell Project were analysed and a new model (T cell score), based on four covariates (serum albumin, performance status, stage and absolute neutrophil count) that maintained their prognostic value in multiple Cox proportional hazards regression analysis was proposed. Among patients registered in the T Cell Project, 311 PTCL-NOS were retained for study. At a median follow-up of 46 months, the median overall survival (OS) and progression-free survival (PFS) was 20 and 10 months, respectively. Three groups were identified at low risk (LR, 48 patients, 15%, score 0), intermediate risk (IR, 189 patients, 61%, score 1–2), and high risk (HiR, 74 patients, 24%, score 3–4), having a 3-year OS of 76% [95% confidence interval 61–88], 43% [35–51], and 11% [4–21], respectively (P < 0·001). Comparing the performance of the T cell score on OS to that of each of the previously developed models, it emerged that the new score had the best discriminant power. The new T cell score, based on clinical variables, identifies a group with very unfavourable outcomes.
KW - PTCL-NOS
KW - clinical variables
KW - prognostic index
KW - risk factors
KW - survival
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U2 - 10.1111/bjh.15258
DO - 10.1111/bjh.15258
M3 - Article
C2 - 29672827
AN - SCOPUS:85048549039
SN - 0007-1048
VL - 181
SP - 760
EP - 769
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 6
ER -