Peripheral tissues, alphaherpesviruses and the cytoskeleton in neuronal infections

Sofia V. Zaichick, Kevin P. Bohannon, Gregory A. Smith

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Following infection of exposed neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.

Original languageEnglish (US)
Pages (from-to)941-981
Number of pages41
JournalViruses
Volume3
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Alphaherpesvirus
  • Cytoskeleton
  • Neuroinvasion
  • Virus transport

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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