Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons

A. M. Morris*, L. Huang, P. Bacchetti, J. Turner, P. C. Hopewell, J. M. Wallace, P. A. Kvale, M. J. Rosen, J. Glassroth, L. B. Reichman, J. D. Stansell, C. Merrifield, D. Osmond, R. Hirschtick, M. Mossar, K. K. Manghisi, L. Meiselman, R. F. Schneider, S. Barnes, B. T. ManguraJ. Au, B. Browdy, V. Clemente, A. Coulson, B. Richer, J. Sayre, J. Huitsing, C. Johnson, A. Krystoforski, N. Markowitz, L. D. Saravolatz, W. Fulkerson, W. K. Poole, K. Clayton, N. I. Hansen, M. C. Jordan, J. Katzin, L. LaVange, D. Myers, A. V. Rao, J. Thompson, T. Wilcosky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Human immunodeficiency virus (HIV)-associated respiratory infections, most notably Pneumocystis carinii pneumonia (PCP), but also bacterial pneumonia (BP), result in reductions in lung function that have been studied mainly during the course of acute infection. Whether HIV-associated pneumonias also cause permanent changes in pulmonary function is unknown. In this study we investigated the long-term effects of PCP and BP on pulmonary function in a cohort of HIV-infected persons. One thousand, one hundred forty-nine HIV-infected persons were followed in a prospective, observational cohort study at six centers in the United States. Study participants had pulmonary function testing performed at regular preset intervals. PCP and BP diagnoses were verified with defined criteria. Longitudinal multivariate analysis was used to model pulmonary function in terms of demographic data and occurrence of PCP or BP. We found that PCP or BP was associated with permanent decreases in FEV1, FVC, FEV1/FVC, and the diffusing capacity of carbon monoxide. Neither infection resulted in statistically significant changes in TLC. We conclude that PCP and BP result in expiratory airflow reductions that persist after the acute infection resolves. The clinical implications of these changes are unknown, but they may contribute to prolonged respiratory complaints in HIV-infected patients who have had pneumonia.

Original languageEnglish (US)
Pages (from-to)612-616
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Issue number2 I
StatePublished - 2000

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Permanent declines in pulmonary function following pneumonia in human immunodeficiency virus-infected persons'. Together they form a unique fingerprint.

Cite this