Abstract
Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.
| Original language | Spanish |
|---|---|
| Pages (from-to) | 378-382 |
| Number of pages | 5 |
| Journal | Archivos de Bronconeumologia |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 2010 |
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Keywords
- Acute lung injury
- Hypercapnia
- Lung injury
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
}
Hipercapnia permisiva o no permisiva : mecanismos de acción y consecuencias de altos niveles de dióxido de carbono. / Briva, Arturo; Lecuona, Emilia; Sznajder, Jacob I.
In: Archivos de Bronconeumologia, Vol. 46, No. 7, 01.01.2010, p. 378-382.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Hipercapnia permisiva o no permisiva
T2 - mecanismos de acción y consecuencias de altos niveles de dióxido de carbono
AU - Briva, Arturo
AU - Lecuona, Emilia
AU - Sznajder, Jacob I
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.
AB - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.
KW - Acute lung injury
KW - Hypercapnia
KW - Lung injury
UR - http://www.scopus.com/inward/record.url?scp=77954059349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954059349&partnerID=8YFLogxK
U2 - 10.1016/j.arbres.2010.01.009
DO - 10.1016/j.arbres.2010.01.009
M3 - Short survey
VL - 46
SP - 378
EP - 382
JO - Archivos de Bronconeumologia
JF - Archivos de Bronconeumologia
SN - 0300-2896
IS - 7
ER -