Hipercapnia permisiva o no permisiva: mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

Arturo Briva; Emilia Lecuona; Jacob I. Sznajder

doi:10.1016/j.arbres.2010.01.009

Hipercapnia permisiva o no permisiva: mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

Translated title of the contribution: Permissive and non-permissive hypercapnia: Mechanisms of action and consequences of high carbon dioxide levels

Arturo Briva^*, Emilia Lecuona, Jacob I. Sznajder

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO₂ beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO₂ during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

Translated title of the contribution	Permissive and non-permissive hypercapnia: Mechanisms of action and consequences of high carbon dioxide levels
Original language	Spanish
Pages (from-to)	378-382
Number of pages	5
Journal	Archivos de Bronconeumologia
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.arbres.2010.01.009
State	Published - Jul 2010

Keywords

Acute lung injury
Hypercapnia
Lung injury

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.arbres.2010.01.009

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title = "Hipercapnia permisiva o no permisiva: mecanismos de acci{\'o}n y consecuencias de altos niveles de di{\'o}xido de carbono",

abstract = "Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.",

keywords = "Acute lung injury, Hypercapnia, Lung injury",

author = "Arturo Briva and Emilia Lecuona and Sznajder, {Jacob I.}",

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T2 - mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

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AU - Lecuona, Emilia

AU - Sznajder, Jacob I.

PY - 2010/7

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N2 - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

AB - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

KW - Acute lung injury

KW - Hypercapnia

KW - Lung injury

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Hipercapnia permisiva o no permisiva: mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

Abstract

Keywords

ASJC Scopus subject areas

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