Hipercapnia permisiva o no permisiva

mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

Translated title of the contribution: Permissive and non-permissive hypercapnia: Mechanisms of action and consequences of high carbon dioxide levels

Arturo Briva*, Emilia Lecuona, Jacob I Sznajder

*Corresponding author for this work

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

Original languageSpanish
Pages (from-to)378-382
Number of pages5
JournalArchivos de Bronconeumologia
Volume46
Issue number7
DOIs
StatePublished - Jan 1 2010

Fingerprint

Hypercapnia
Acute Lung Injury
Carbon Dioxide
Lung Injury
Artificial Respiration
Mortality
Incidence
Therapeutics

Keywords

  • Acute lung injury
  • Hypercapnia
  • Lung injury

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Hipercapnia permisiva o no permisiva: mecanismos de acci{\'o}n y consecuencias de altos niveles de di{\'o}xido de carbono",
abstract = "Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.",
keywords = "Acute lung injury, Hypercapnia, Lung injury",
author = "Arturo Briva and Emilia Lecuona and Sznajder, {Jacob I}",
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T2 - mecanismos de acción y consecuencias de altos niveles de dióxido de carbono

AU - Briva, Arturo

AU - Lecuona, Emilia

AU - Sznajder, Jacob I

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

AB - Acute lung injury is a disease with high incidence of mortality and its treatment is still controversial. Increasing the levels of CO2 beyond the physiological range has been proposed as a potential protective strategy for patients on mechanical ventilation, as it could moderate the inflammatory response. In this article we review the published evidence on the role of CO2 during acute lung injury. We conclude that although there are reports suggesting benefits from hypercapnia, more recent evidence suggests that hypercapnia could be deleterious, contributing to worsening of the lung injury.

KW - Acute lung injury

KW - Hypercapnia

KW - Lung injury

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U2 - 10.1016/j.arbres.2010.01.009

DO - 10.1016/j.arbres.2010.01.009

M3 - Short survey

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EP - 382

JO - Archivos de Bronconeumologia

JF - Archivos de Bronconeumologia

SN - 0300-2896

IS - 7

ER -