Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by cipro-fibrate in the rat

M. S. Rao; S. Thangada; V. Subbarao

doi:10.1016/S0232-1513(11)80045-9

Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by cipro-fibrate in the rat

M. S. Rao^*, S. Thangada, V. Subbarao

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced in the rat by ciprofibrate were analyzed for peroxisome proliferation. The volume density of peroxisomes in NN and HCC was 5.7 ± 2.7 and 6.6 ± 2.9, respectively; whereas in adjacent uninvolved liver the volume density was 16.3 ± 5.0. No ultrastructural differences between NN were found to discriminate nodule from carcinoma. The results of this study indicate that the peroxisome proliferative response of NN and HCC to ciprofibrate is similar and can not be used as a marker to differentiate these lesions.

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	Experimental Pathology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/S0232-1513(11)80045-9
State	Published - 1991

Keywords

ciprofibrate
hepatocellular carcinoma
neoplastic nodules
peroxisome

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S0232-1513(11)80045-9

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title = "Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by cipro-fibrate in the rat",

abstract = "Neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced in the rat by ciprofibrate were analyzed for peroxisome proliferation. The volume density of peroxisomes in NN and HCC was 5.7 ± 2.7 and 6.6 ± 2.9, respectively; whereas in adjacent uninvolved liver the volume density was 16.3 ± 5.0. No ultrastructural differences between NN were found to discriminate nodule from carcinoma. The results of this study indicate that the peroxisome proliferative response of NN and HCC to ciprofibrate is similar and can not be used as a marker to differentiate these lesions.",

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year = "1991",

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T1 - Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by cipro-fibrate in the rat

AU - Rao, M. S.

AU - Thangada, S.

AU - Subbarao, V.

PY - 1991

Y1 - 1991

N2 - Neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced in the rat by ciprofibrate were analyzed for peroxisome proliferation. The volume density of peroxisomes in NN and HCC was 5.7 ± 2.7 and 6.6 ± 2.9, respectively; whereas in adjacent uninvolved liver the volume density was 16.3 ± 5.0. No ultrastructural differences between NN were found to discriminate nodule from carcinoma. The results of this study indicate that the peroxisome proliferative response of NN and HCC to ciprofibrate is similar and can not be used as a marker to differentiate these lesions.

AB - Neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced in the rat by ciprofibrate were analyzed for peroxisome proliferation. The volume density of peroxisomes in NN and HCC was 5.7 ± 2.7 and 6.6 ± 2.9, respectively; whereas in adjacent uninvolved liver the volume density was 16.3 ± 5.0. No ultrastructural differences between NN were found to discriminate nodule from carcinoma. The results of this study indicate that the peroxisome proliferative response of NN and HCC to ciprofibrate is similar and can not be used as a marker to differentiate these lesions.

KW - ciprofibrate

KW - hepatocellular carcinoma

KW - neoplastic nodules

KW - peroxisome

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Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by cipro-fibrate in the rat

Abstract

Keywords

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