Abstract
Spontaneous peroxisome proliferation-related pleiotropic responses occurring in the liver of mice lacking peroxisomal fatty acyl-CoA oxidase (AOX-/-) are attributed to sustained activation of peroxisome proliferator-activated receptor α (PPARα) by its putative natural ligands that require AOX for their metabolism. In this study, using a gene expression screen, we show that Ly-6 (lymphocyte antigen 6 complex, locus D; mouse ThB), which belongs to a distinctive family of low molecular weight phosphatidyl inositol anchored cell surface glycoproteins, is upregulated in mouse liver with peroxisome proliferation. Increases in Ly-6D mRNA levels are observed in AOX-/- mouse liver with spontaneous peroxisome proliferation and also in the liver of wild-type mice treated with synthetic peroxisome proliferators. Peroxisome proliferators failed to increase hepatic Ly-6D mRNA levels in mice lacking PPARα (PPARα-/-), suggesting a regulatory role for PPARα in the induction of Ly-6D. These observations suggest that changes in certain cell surface proteins also form part of the pleiotropic responses associated with peroxisome proliferation.
Original language | English (US) |
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Pages (from-to) | 173-181 |
Number of pages | 9 |
Journal | Gene expression |
Volume | 9 |
Issue number | 4-5 |
DOIs | |
State | Published - 2001 |
Keywords
- Fatty acyl-CoA oxidase
- Ly-6D
- PPARα
- Peroxisome proliferators
ASJC Scopus subject areas
- Genetics
- Molecular Biology