Peroxisome proliferator-activated receptor α-dependent induction of cell surface antigen Ly-6D gene in the mouse liver

S. S. Dadras, W. S. Cook, A. V. Yeldandi, W. Q. Cao, M. S. Rao, Z. Wang, J. K. Reddy*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Spontaneous peroxisome proliferation-related pleiotropic responses occurring in the liver of mice lacking peroxisomal fatty acyl-CoA oxidase (AOX-/-) are attributed to sustained activation of peroxisome proliferator-activated receptor α (PPARα) by its putative natural ligands that require AOX for their metabolism. In this study, using a gene expression screen, we show that Ly-6 (lymphocyte antigen 6 complex, locus D; mouse ThB), which belongs to a distinctive family of low molecular weight phosphatidyl inositol anchored cell surface glycoproteins, is upregulated in mouse liver with peroxisome proliferation. Increases in Ly-6D mRNA levels are observed in AOX-/- mouse liver with spontaneous peroxisome proliferation and also in the liver of wild-type mice treated with synthetic peroxisome proliferators. Peroxisome proliferators failed to increase hepatic Ly-6D mRNA levels in mice lacking PPARα (PPARα-/-), suggesting a regulatory role for PPARα in the induction of Ly-6D. These observations suggest that changes in certain cell surface proteins also form part of the pleiotropic responses associated with peroxisome proliferation.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalGene expression
Volume9
Issue number4-5
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Fatty acyl-CoA oxidase
  • Ly-6D
  • PPARα
  • Peroxisome proliferators

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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