Peroxisome proliferator-activated receptors and liver X receptors in atherosclerosis and immunity

Grant D. Barish*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Atherosclerosis is a primary cause of death in the United States, and the current obesity epidemic threatens to exacerbate its morbidity and mortality worldwide. Despite important cardiovascular treatment advances over the past few decades, new approaches are needed to curb dangerous health trends. Nuclear receptors are a superfamily of ligand-activated transcription factors. The discovery of subfamilies known as peroxisome proliferator-activated receptors (PPAR) and liver X receptors (LXR) as lipid-sensors that regulate lipid and glucose metabolismas well as inflammation offers new targets for nutritional and pharmacologic treatment of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)690-694
Number of pages5
JournalJournal of Nutrition
Volume136
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Atherosclerosis
  • Liver X receptors
  • Peroxisome proliferator-activated receptors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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