Plasticizers (e.g. di-(2-ethylhexyl)-pthalate (DEHP)) in common use in PVC plastics and hypolipidemic drugs (e.g. clofibrate) are two types of compound is to which we may be frequently exposed. Yet these are among a group of diverse compounds which cause hepatic peroxisome proliferation, a condition which can lead to hepatic cancer by non-mutagenic means. Janardan Reddy and Sambasiva Rao discuss the possible mechanisms of induction of peroxisome proliferator pleiotropic responses leading to the development of liver tumors, focusing in particular on the hypothesis that the mechanism involves a single biological receptor, or a set of receptors.
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