Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5Δ32 allele

Paul R. Gorry, Chengsheng Zhang, Sam Wu, Kevin Kunstman, Elizabeth Trachtenberg, John Phair, Steven Wolinsky, Dana Gabuzda*

*Corresponding author for this work

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of white people are homozygous for a non-functional CCR5 allele, containing a 32 base pair deletion (CCR5Δ32). We studied the persistence of dual-tropic HIV-1 in an individual homozygous for this deletion. Our results suggest that structural features of the HIV-1 envelope linked to CCR5 tropism could confer a selective advantage in vivo.

Original languageEnglish (US)
Pages (from-to)1832-1834
Number of pages3
JournalLancet
Volume359
Issue number9320
DOIs
StatePublished - May 25 2002

ASJC Scopus subject areas

  • Medicine(all)

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    Gorry, P. R., Zhang, C., Wu, S., Kunstman, K., Trachtenberg, E., Phair, J., Wolinsky, S., & Gabuzda, D. (2002). Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5Δ32 allele. Lancet, 359(9320), 1832-1834. https://doi.org/10.1016/S0140-6736(02)08681-6