Persistence of efficacy after a brief course of polymerized ragweed allergen: A controlled study

Leslie C. Grammer*, Martha A. Shaughnessy, Irena M. Suszko, John J. Shaughnessy, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Immunotherapy with PRW has been demonstrated to be safe and effective. To determine whether the efficacy would remain in successive ragweed seasons without further therapy, a trial was conducted comparing PRW to histamine placebo therapy in patients that had received courses of PRW previously. Those patients were also compared to previously untreated ragweed-sensitive patients. In a double-blind fashion, 21 previously treated patients were treated before the 1982 ragweed season with four weekly injections of PRW therapy, whereas 21 previously treated patients were treated with four injections of placebo therapy. An additional control group of 21 previously untreated ragweed-sensitive patients received no injections. Daily symptom and medication score sheets were completed by patients each day of the ragweed season. Blocking antibody rose elevenfold with treatment (p < 0.0001) in the PRW group. There was a statistically significant difference in symptom score mean between untreated patients (1007 ± 174) and previously treated patients whether they received supplemental injections (554 ± 180) (p < 0.01) or whether they did not (650 ± 168) (p < 0.03). In summary the efficacy of 15 injections of PRW immunotherapy persists at least several years without need for supplemental immunotherapy.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalThe Journal of allergy and clinical immunology
Issue number4
StatePublished - Apr 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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