Persistence of human papillomavirus infection: Keys to malignant progression

Jason Bodily; Laimonis A. Laimins

doi:10.1016/j.tim.2010.10.002

Persistence of human papillomavirus infection: Keys to malignant progression

Jason Bodily, Laimonis A. Laimins^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Review article › peer-review

267 Scopus citations

Abstract

Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.

Original language	English (US)
Pages (from-to)	33-39
Number of pages	7
Journal	Trends in Microbiology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.tim.2010.10.002
State	Published - Jan 2011

Funding

We thank Dr Jian-Jun Wei, Department of Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University for helpful advice and Kristina Simanis for assistance with diagrams. L.A.L. was supported by grants from the National Cancer Institute.

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2010.10.002

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title = "Persistence of human papillomavirus infection: Keys to malignant progression",

abstract = "Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.",

author = "Jason Bodily and Laimins, {Laimonis A.}",

note = "Funding Information: We thank Dr Jian-Jun Wei, Department of Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University for helpful advice and Kristina Simanis for assistance with diagrams. L.A.L. was supported by grants from the National Cancer Institute. ",

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AU - Laimins, Laimonis A.

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N2 - Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.

AB - Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.

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Persistence of human papillomavirus infection: Keys to malignant progression

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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