TY - JOUR
T1 - Persistence of human papillomavirus infection
T2 - Keys to malignant progression
AU - Bodily, Jason
AU - Laimins, Laimonis A.
N1 - Funding Information:
We thank Dr Jian-Jun Wei, Department of Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University for helpful advice and Kristina Simanis for assistance with diagrams. L.A.L. was supported by grants from the National Cancer Institute.
PY - 2011/1
Y1 - 2011/1
N2 - Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.
AB - Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.
UR - http://www.scopus.com/inward/record.url?scp=78650748371&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650748371&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2010.10.002
DO - 10.1016/j.tim.2010.10.002
M3 - Review article
C2 - 21050765
AN - SCOPUS:78650748371
SN - 0966-842X
VL - 19
SP - 33
EP - 39
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 1
ER -
