Persistence of human papillomavirus infection: Keys to malignant progression

Jason Bodily, Laimonis A. Laimins*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

187 Scopus citations

Abstract

Human papillomaviruses (HPVs) are the etiologic agents of cervical and other epithelial cancers. Persistence of infections by high-risk HPV types is the single greatest risk factor for malignant progression. Although prophylactic vaccines have been developed that target high-risk HPV types, there is a continuing need to understand better the virus-host interactions that underlie persistent benign infection and progression to cancer. In this review we summarize the molecular events that facilitate the differentiation-dependent HPV life cycle, how the life cycle is organized to facilitate virus persistence, and how the activities of HPV regulatory proteins result in malignancy.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalTrends in Microbiology
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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