Persistent neutrophil dysfunction in an adult. Combined defect in chemotaxis, phagocytosis and intracellular killing

James S. Tan*, Ronald G. Strauss, John Akabutu, Carol A. Kauffman, Alvin M. Mauer, John P. Phair

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Impaired phagocytosis and killing of bacteria by neutrophils were demonstrated repeatedly in a 65 year old man. He had staphylococcal pyarthrosis and osteomyelitis. Phagocytosis and intracellular killing of Staphylococcus aureus by neutrophils of the patient were impaired, but no significant defect was noted when Candida was used as the test organism. Production of 14CO2 from glucose-1-14C, glucose-6-phosphate dehydrogenase levels, nitroblue tetrazolium reduction test and myeloperoxidase levels were all normal in his neutrophils. The monocyte bactericidal capacity for Staph. aureus was normal. Despite normal migration demonstrated by the skin window technic and by the presence of numerous neutrophils in the joint aspirate, studies of neutrophil chemotaxis revealed an impaired response to chemotaxin, and an inhibitor of chemotaxis of normal neutrophils was also found in his serum. However, his serum generated chemotaxin normally. This neutrophil dysfunction appears to differ from that found in chronic granulomatous disease of childhood and other known defects of neutrophil function.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalThe American journal of medicine
Volume57
Issue number2
DOIs
StatePublished - Aug 1974

Fingerprint

Chemotaxis
Phagocytosis
Neutrophils
Chemotactic Factors
Skin Window Technique
Nitroblue Tetrazolium
Chronic Granulomatous Disease
Glucosephosphate Dehydrogenase
Osteomyelitis
Serum
Candida
Peroxidase
Staphylococcus aureus
Monocytes
Joints
Bacteria
Glucose

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tan, James S. ; Strauss, Ronald G. ; Akabutu, John ; Kauffman, Carol A. ; Mauer, Alvin M. ; Phair, John P. / Persistent neutrophil dysfunction in an adult. Combined defect in chemotaxis, phagocytosis and intracellular killing. In: The American journal of medicine. 1974 ; Vol. 57, No. 2. pp. 251-258.
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abstract = "Impaired phagocytosis and killing of bacteria by neutrophils were demonstrated repeatedly in a 65 year old man. He had staphylococcal pyarthrosis and osteomyelitis. Phagocytosis and intracellular killing of Staphylococcus aureus by neutrophils of the patient were impaired, but no significant defect was noted when Candida was used as the test organism. Production of 14CO2 from glucose-1-14C, glucose-6-phosphate dehydrogenase levels, nitroblue tetrazolium reduction test and myeloperoxidase levels were all normal in his neutrophils. The monocyte bactericidal capacity for Staph. aureus was normal. Despite normal migration demonstrated by the skin window technic and by the presence of numerous neutrophils in the joint aspirate, studies of neutrophil chemotaxis revealed an impaired response to chemotaxin, and an inhibitor of chemotaxis of normal neutrophils was also found in his serum. However, his serum generated chemotaxin normally. This neutrophil dysfunction appears to differ from that found in chronic granulomatous disease of childhood and other known defects of neutrophil function.",
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Persistent neutrophil dysfunction in an adult. Combined defect in chemotaxis, phagocytosis and intracellular killing. / Tan, James S.; Strauss, Ronald G.; Akabutu, John; Kauffman, Carol A.; Mauer, Alvin M.; Phair, John P.

In: The American journal of medicine, Vol. 57, No. 2, 08.1974, p. 251-258.

Research output: Contribution to journalArticle

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