Persistent pain inhibits contralateral somatosensory cortical activity in humans

A. Vania Apkarian; Richard A. Stea; Stephen H. Manglos; Nikolaus M. Szeverenyi; Robert B. King; F. Deaver Thomas

doi:10.1016/0304-3940(92)90088-O

Persistent pain inhibits contralateral somatosensory cortical activity in humans

A. Vania Apkarian^*, Richard A. Stea, Stephen H. Manglos, Nikolaus M. Szeverenyi, Robert B. King, F. Deaver Thomas

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change distribution. Contralateral somatosensory rCBF was decreased when the digits of the hand were immersed in a hot water bath for 3 min which was rated as moderately painful (persistent pain). No decrease was observed when the hand was immersed in tepid water (control). In contrast, cortical rCBF was increased during vibratory and sensorimotor tasks, in the contralateral somatosensory and sensorimotor areas, respectively. These results indicate that pain perception in man is associated with somatosensory cortical inhibition.

Original language	English (US)
Pages (from-to)	141-147
Number of pages	7
Journal	Neuroscience Letters
Volume	140
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(92)90088-O
State	Published - Jun 22 1992

Funding

We thankA . Rosenbaumfo r adviceo n MRI imaging; ER. Sheehef or advice on statistical analyseJ.sD;. Greenspafno r participatinign the project;F . Marano for constructintgh e dentalp lates;J. W. Holsapplefo r helpi n the designa ndJ. Mainesa ndE. Dixon for con-structingth eheadholder; anBd.R, . Krauss,T . and M. DuxburyJ,. J. Morrow andM . Formikelflo re xpertte ch-nicala ssistanceT.h is studyw asp artially supportbeyd a grant from Hendrick'sF oundationN, S-228910a nd MediPhysic(sA mershamb)y supplyinCg eretec.

Keywords

Cerebral blood flow
Cortical inhibition
Functional imaging
HMPAO
Human
Pain
SPECT

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(92)90088-O

Cite this

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title = "Persistent pain inhibits contralateral somatosensory cortical activity in humans",

abstract = "To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change distribution. Contralateral somatosensory rCBF was decreased when the digits of the hand were immersed in a hot water bath for 3 min which was rated as moderately painful (persistent pain). No decrease was observed when the hand was immersed in tepid water (control). In contrast, cortical rCBF was increased during vibratory and sensorimotor tasks, in the contralateral somatosensory and sensorimotor areas, respectively. These results indicate that pain perception in man is associated with somatosensory cortical inhibition.",

keywords = "Cerebral blood flow, Cortical inhibition, Functional imaging, HMPAO, Human, Pain, SPECT",

author = "Apkarian, {A. Vania} and Stea, {Richard A.} and Manglos, {Stephen H.} and Szeverenyi, {Nikolaus M.} and King, {Robert B.} and Thomas, {F. Deaver}",

note = "Funding Information: We thankA . Rosenbaumfo r adviceo n MRI imaging; ER. Sheehef or advice on statistical analyseJ.sD;. Greenspafno r participatinign the project;F . Marano for constructintgh e dentalp lates;J. W. Holsapplefo r helpi n the designa ndJ. Mainesa ndE. Dixon for con-structingth eheadholder; anBd.R, . Krauss,T . and M. DuxburyJ,. J. Morrow andM . Formikelflo re xpertte ch-nicala ssistanceT.h is studyw asp artially supportbeyd a grant from Hendrick'sF oundationN, S-228910a nd MediPhysic(sA mershamb)y supplyinCg eretec.",

year = "1992",

month = jun,

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doi = "10.1016/0304-3940(92)90088-O",

language = "English (US)",

volume = "140",

pages = "141--147",

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AU - Apkarian, A. Vania

AU - Stea, Richard A.

AU - Manglos, Stephen H.

AU - Szeverenyi, Nikolaus M.

AU - King, Robert B.

AU - Thomas, F. Deaver

N1 - Funding Information: We thankA . Rosenbaumfo r adviceo n MRI imaging; ER. Sheehef or advice on statistical analyseJ.sD;. Greenspafno r participatinign the project;F . Marano for constructintgh e dentalp lates;J. W. Holsapplefo r helpi n the designa ndJ. Mainesa ndE. Dixon for con-structingth eheadholder; anBd.R, . Krauss,T . and M. DuxburyJ,. J. Morrow andM . Formikelflo re xpertte ch-nicala ssistanceT.h is studyw asp artially supportbeyd a grant from Hendrick'sF oundationN, S-228910a nd MediPhysic(sA mershamb)y supplyinCg eretec.

PY - 1992/6/22

Y1 - 1992/6/22

N2 - To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change distribution. Contralateral somatosensory rCBF was decreased when the digits of the hand were immersed in a hot water bath for 3 min which was rated as moderately painful (persistent pain). No decrease was observed when the hand was immersed in tepid water (control). In contrast, cortical rCBF was increased during vibratory and sensorimotor tasks, in the contralateral somatosensory and sensorimotor areas, respectively. These results indicate that pain perception in man is associated with somatosensory cortical inhibition.

AB - To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change distribution. Contralateral somatosensory rCBF was decreased when the digits of the hand were immersed in a hot water bath for 3 min which was rated as moderately painful (persistent pain). No decrease was observed when the hand was immersed in tepid water (control). In contrast, cortical rCBF was increased during vibratory and sensorimotor tasks, in the contralateral somatosensory and sensorimotor areas, respectively. These results indicate that pain perception in man is associated with somatosensory cortical inhibition.

KW - Cerebral blood flow

KW - Cortical inhibition

KW - Functional imaging

KW - HMPAO

KW - Human

KW - Pain

KW - SPECT

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ER -

Persistent pain inhibits contralateral somatosensory cortical activity in humans

Abstract

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Keywords

ASJC Scopus subject areas

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