Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease

Rena Yadlapati*, John E. Pandolfino

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.

Original languageEnglish (US)
Pages (from-to)227-238
Number of pages12
JournalGastrointestinal Endoscopy Clinics of North America
Issue number2
StatePublished - Apr 2020


  • Esophageal manometry
  • Esophagitis
  • Functional heartburn
  • Hiatal hernia
  • Proton pump inhibitor
  • Reflux
  • Supragastric belching
  • Transient lower esophageal sphincter relaxation

ASJC Scopus subject areas

  • Gastroenterology


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