Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease

Rena Yadlapati; John E. Pandolfino

doi:10.1016/j.giec.2019.12.002

Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease

Rena Yadlapati^*, John E. Pandolfino

^*Corresponding author for this work

Medicine, Gastroenterology Division

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.

Original language	English (US)
Pages (from-to)	227-238
Number of pages	12
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.giec.2019.12.002
State	Published - Apr 2020

Funding

Research Support: Dr R. Yadlapati is supported by the ACG Research Institute – Junior Faculty Development Award (R. Yadlapati). Dr R. Yadlapati and Dr J.E. Pandolfino are supported by the NIH R01DK092217-04A1 (J.E. Pandolfino).

Keywords

Esophageal manometry
Esophagitis
Functional heartburn
Hiatal hernia
Proton pump inhibitor
Reflux
Supragastric belching
Transient lower esophageal sphincter relaxation

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.giec.2019.12.002

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title = "Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease",

abstract = "Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.",

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AB - Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.

KW - Esophageal manometry

KW - Esophagitis

KW - Functional heartburn

KW - Hiatal hernia

KW - Proton pump inhibitor

KW - Reflux

KW - Supragastric belching

KW - Transient lower esophageal sphincter relaxation

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Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease

Abstract

Funding

Keywords

ASJC Scopus subject areas

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