Perspectives on Dexmedetomidine Use for Neurosurgical Patients

Nan Lin, Laszlo Vutskits, John F. Bebawy, Adrian W. Gelb*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The α2-Adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting evidence regarding both its common and controversial uses.

Original languageEnglish (US)
Pages (from-to)366-377
Number of pages12
JournalJournal of Neurosurgical Anesthesiology
Issue number4
StatePublished - Oct 1 2019


  • dexmedetomidine
  • neuroanesthesia
  • neurosurgical anesthesia
  • perioperative care

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Surgery


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