Perspectives on Dexmedetomidine Use for Neurosurgical Patients

Nan Lin; Laszlo Vutskits; John F. Bebawy; Adrian W. Gelb

doi:10.1097/ANA.0000000000000554

Perspectives on Dexmedetomidine Use for Neurosurgical Patients

Nan Lin, Laszlo Vutskits, John F. Bebawy, Adrian W. Gelb^*

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

The α2-Adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting evidence regarding both its common and controversial uses.

Original language	English (US)
Pages (from-to)	366-377
Number of pages	12
Journal	Journal of Neurosurgical Anesthesiology
Volume	31
Issue number	4
DOIs	https://doi.org/10.1097/ANA.0000000000000554
State	Published - Oct 1 2019

Funding

Supported by Beijing Municipal Administration of Hospitals’ Youth Program (QML20160503) and by the National Natural Science Foundation of China (Grant No.1701038).

Keywords

dexmedetomidine
neuroanesthesia
neurosurgical anesthesia
perioperative care

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine
Surgery

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abstract = "The α2-Adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting evidence regarding both its common and controversial uses.",

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AB - The α2-Adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting evidence regarding both its common and controversial uses.

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KW - perioperative care

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Perspectives on Dexmedetomidine Use for Neurosurgical Patients

Abstract

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Keywords

ASJC Scopus subject areas

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