TY - JOUR
T1 - Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation
T2 - Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology
AU - the SCEDO-LUNG collaborative group
AU - Rammaert, Blandine
AU - Puyade, Mathieu
AU - Cornely, Oliver A.
AU - Seidel, Danila
AU - Grossi, Paolo
AU - Husain, Shahid
AU - Picard, Clément
AU - Lass-Flörl, Cornelia
AU - Manuel, Oriol
AU - Le Pavec, Jérôme
AU - Lortholary, Olivier
AU - Nagel, Claudia
AU - Westall, Glen
AU - Morrissey, Orla
AU - Chambers, Daniel
AU - Eschertzhuber, Stephan
AU - Coussement, Julien
AU - Knoop, Christiane
AU - Vos, Robin
AU - Dupont, Lieven
AU - Dumonceaux, Michel
AU - Campos, Silvia Vidal
AU - Kabbani, Dima
AU - Cervera, Carlos
AU - Luong, Me Linh
AU - Blanchard, Elodie
AU - Sénéchal, Agathe
AU - Pavec, Jérôme Le
AU - Brugière, Olivier
AU - Boussaud, Veronique
AU - Guillemain, Romain
AU - Bervar, Jean Francois
AU - Claustre, Johanna
AU - Haloun, Alain
AU - Hirschi, Sandrine
AU - Reynaud, Martine
AU - Kneidinger, Nikolaus
AU - Gottlieb, Jens
AU - Roilides, Emmanuel
AU - Zarrinfar, Hossein
AU - Rosso, Lorenzo
AU - Morlacchi, Letizia Corinna
AU - Dell'Amore, Andrea
AU - Loy, Monica
AU - Santos, Claudy Oliveira dos
AU - Rello, Jordi
AU - Monforte, Victor
AU - Martin-Gomez, Maria Teresa
AU - Bhorade, Sangeeta
AU - Ison, Michael
N1 - Funding Information:
The authors thank all the people who helped to collect mycological data and to contact transplant centers: Alejandro Mario Bertolotti (Buenos Aires, Argentina), Claire Heney (Brisbane, Australia), Carlota Montesinos (Brussels, Belgium), Katrien Lagrou (Leuven, Belgium), Youri Gluczynski (Yvoir, Belgium), Sandrine Houze (Paris, France), Eric Dannaoui (Paris, France), Florent Morio (Nantes, France), Murielle Cornet (Grenoble, France), Val?rie Bru (Strasbourg, France), St?phane Ranque (Marseille, France), Emilie Cardot (Suresnes, France), Ludwig Sedlacek (Hannover, Germany), Maurizio Sanguinetti (Roma, Italy), Ana Alastruey (Madrid, Spain), Konrad Muehlethaler (Bern, Switzerland), Kevin Alby (Philadelphia, USA), Malcom Richardson (Manchester, UK); the members of the ESCMID Fungal Infection Study Group (EFISG) and Study Group for Infections in Compromised Hosts (ESGICH) and European Confederation of Medical Mycology (ECMM) who helped to promote the study; Jeffrey Arsham for editing our original English language manuscript.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
AB - Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
KW - invasive fungal disease
KW - lomentosporiosis
KW - scedosporiosis
KW - solid organ transplantation
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U2 - 10.1111/tid.13141
DO - 10.1111/tid.13141
M3 - Article
C2 - 31283872
AN - SCOPUS:85069887016
VL - 21
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 5
M1 - e13141
ER -