Perspectives on whole-organ assembly: Moving toward transplantation on demand

Alejandro Soto-Gutierrez*, Jason A. Wertheim, Harald C. Ott, Thomas W. Gilbert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.

Original languageEnglish (US)
Pages (from-to)3817-3823
Number of pages7
JournalJournal of Clinical Investigation
Volume122
Issue number11
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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