Abstract
Aphasias are caused by disruption in structural integrity and interconnectivity within a large-scale distributed language network. We investigated the distribution and behavioral consequences of altered functional connectivity in three variants of primary progressive aphasia (PPA). The goal was to clarify relationships among atrophy, resting connectivity, and the resulting behavioral changes in 73 PPA and 33 control participants. Three core regions of the left perisylvian language network: the inferior frontal gyrus (IFG), middle temporal gyrus (MTG), and anterior temporal lobe (ATL) were evaluated in agrammatic (PPA-G), logopenic (PPA-L), and semantic (PPA-S) PPA variants. All PPA groups showed decreased connectivity between IFG and MTG. The PPA-S group also showed additional loss of connectivity strength between ATL and the other language regions. Decreased connectivity between the IFG and MTG nodes in PPA-G remained significant even when controlled for the effect of atrophy. In the PPA group as a whole, IFG-MTG connectivity strength correlated with repetition and grammar scores, whereas MTG-ATL connectivity correlated with picture naming and single-word comprehension. There was no significant change in the connectivity of homologous regions in the right hemisphere. These results show that language impairments in PPA are associated with perturbations of functional connectivity within behaviorally concordant components of the language network. Altered connectivity in PPA may reflect not only the irreversible loss of cortical components indexed by atrophy, but also the dysfunction of remaining neurons.
| Original language | English (US) |
|---|---|
| Journal | Cortex |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Aphasia
- Language impairment
- Neuroimaging
- Primary progressive aphasia
- Resting state fMRI
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Experimental and Cognitive Psychology
- Cognitive Neuroscience
Cite this
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Perturbations of language network connectivity in primary progressive aphasia. / Bonakdarpour, Borna; Hurley, Robert S.; Wang, Allan R.; Fereira, Hernando R.; Basu, Anisha; Chatrathi, Arjuna; Guillaume, Kyla; Rogalski, Emily; Mesulam, Marek-Marsel.
In: Cortex, 01.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Perturbations of language network connectivity in primary progressive aphasia
AU - Bonakdarpour, Borna
AU - Hurley, Robert S.
AU - Wang, Allan R.
AU - Fereira, Hernando R.
AU - Basu, Anisha
AU - Chatrathi, Arjuna
AU - Guillaume, Kyla
AU - Rogalski, Emily
AU - Mesulam, Marek-Marsel
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aphasias are caused by disruption in structural integrity and interconnectivity within a large-scale distributed language network. We investigated the distribution and behavioral consequences of altered functional connectivity in three variants of primary progressive aphasia (PPA). The goal was to clarify relationships among atrophy, resting connectivity, and the resulting behavioral changes in 73 PPA and 33 control participants. Three core regions of the left perisylvian language network: the inferior frontal gyrus (IFG), middle temporal gyrus (MTG), and anterior temporal lobe (ATL) were evaluated in agrammatic (PPA-G), logopenic (PPA-L), and semantic (PPA-S) PPA variants. All PPA groups showed decreased connectivity between IFG and MTG. The PPA-S group also showed additional loss of connectivity strength between ATL and the other language regions. Decreased connectivity between the IFG and MTG nodes in PPA-G remained significant even when controlled for the effect of atrophy. In the PPA group as a whole, IFG-MTG connectivity strength correlated with repetition and grammar scores, whereas MTG-ATL connectivity correlated with picture naming and single-word comprehension. There was no significant change in the connectivity of homologous regions in the right hemisphere. These results show that language impairments in PPA are associated with perturbations of functional connectivity within behaviorally concordant components of the language network. Altered connectivity in PPA may reflect not only the irreversible loss of cortical components indexed by atrophy, but also the dysfunction of remaining neurons.
AB - Aphasias are caused by disruption in structural integrity and interconnectivity within a large-scale distributed language network. We investigated the distribution and behavioral consequences of altered functional connectivity in three variants of primary progressive aphasia (PPA). The goal was to clarify relationships among atrophy, resting connectivity, and the resulting behavioral changes in 73 PPA and 33 control participants. Three core regions of the left perisylvian language network: the inferior frontal gyrus (IFG), middle temporal gyrus (MTG), and anterior temporal lobe (ATL) were evaluated in agrammatic (PPA-G), logopenic (PPA-L), and semantic (PPA-S) PPA variants. All PPA groups showed decreased connectivity between IFG and MTG. The PPA-S group also showed additional loss of connectivity strength between ATL and the other language regions. Decreased connectivity between the IFG and MTG nodes in PPA-G remained significant even when controlled for the effect of atrophy. In the PPA group as a whole, IFG-MTG connectivity strength correlated with repetition and grammar scores, whereas MTG-ATL connectivity correlated with picture naming and single-word comprehension. There was no significant change in the connectivity of homologous regions in the right hemisphere. These results show that language impairments in PPA are associated with perturbations of functional connectivity within behaviorally concordant components of the language network. Altered connectivity in PPA may reflect not only the irreversible loss of cortical components indexed by atrophy, but also the dysfunction of remaining neurons.
KW - Aphasia
KW - Language impairment
KW - Neuroimaging
KW - Primary progressive aphasia
KW - Resting state fMRI
UR - http://www.scopus.com/inward/record.url?scp=85072167474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072167474&partnerID=8YFLogxK
U2 - 10.1016/j.cortex.2019.08.010
DO - 10.1016/j.cortex.2019.08.010
M3 - Article
C2 - 31530376
AN - SCOPUS:85072167474
JO - Cortex
JF - Cortex
SN - 0010-9452
ER -