Pertussis toxin prevents the inhibitory effect of adenosine and unmasks adenosine-induced excitation of mammalian motor nerve endings

E. M. Silinsky, J. K. Hirsch, C. Solsona

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Pertussis toxin (PTX), which blocks certain classes of guanine nucleotide binding proteins (G proteins), consistently blocked the inhibitory effects of adenosine (100 μM-250 μM) on quantal acetylcholine (ACh) secretion in rat phrenic nerve hemidiaphragm preparations. PTX pretreatment also highlighted long-lasting increases in evoked ACh release elicited by adenosine. The results suggest that specific G proteins are involved in mediating the inhibitory effects of adenosine at motor nerve endings.

Original languageEnglish (US)
Pages (from-to)16-18
Number of pages3
JournalBritish journal of pharmacology
Volume97
Issue number1
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Pharmacology

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