@article{1d4f0aca2acf4d31b5afbd18079d8542,
title = "Pervasive combinatorial modification of histone H3 in human cells",
abstract = "We developed a platform using hydrophilic interaction chromatography and high-resolution tandem mass spectrometry (MS) for analyses of histone H3 that allows comprehensive characterization of 'histone codes' at the molecular level. We identified over 150 differentially modified forms of histone H3.2 in asynchronously grown and butyrate-treated HeLa cells, revealing pervasive combinatorial modification previously unaccounted for by other techniques and providing a clarified estimate of the molecular diversity of histone H3 in mammals.",
author = "Garcia, {Benjamin A.} and Pesavento, {James J.} and Mizzen, {Craig A.} and Kelleher, {Neil L.}",
note = "Funding Information: Funding from the US National Institutes of Health (NIH; GM 067193), the Packard Foundation, the Alfred P. Sloan Foundation and a 2004 Camille Dreyfus Teacher-Scholar Award from the Dreyfus Foundation to N.L.K., from the Roy J. Carver Charitable Trust (04-76) and the March of Dimes (Basil O{\textquoteright}Connor Scholar Award 5-FY05-1232) to C.A.M., and from the Institute of Genomic Biology at the University of Illinois and the NIH (1 F32 GM 078942-01) to B.A.G. are gratefully acknowledged. J.J.P. is a recipient of an NIH Institutional National Research Service award in Molecular Biophysics (5T32 GM 08276).",
year = "2007",
month = jun,
doi = "10.1038/nmeth1052",
language = "English (US)",
volume = "4",
pages = "487--489",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "Nature Publishing Group",
number = "6",
}