PET/CT and PET/MRI in ophthalmic oncology (Review)

Maria S. Kalemaki, Apostolos H. Karantanas, Dimitris Exarchos, Efstathios T. Detorakis, Odysseas Zoras, Kostas Marias, Corina Millo, Ulas Bagci, Ioannis Pallikaris, Andreas Stratis, Ioannis Karatzanis, Kostas Perisinakis, Pavlos Koutentakis, Georgios A. Kontadakis, Demetrios A. Spandidos, Aristidis Tsatsakis, Georgios Z. Papadakis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Orbital and ocular anatomy is quite complex, consisting of several tissues, which can give rise to both benign and malignant tumors, while several primary neoplasms can metastasize to the orbital and ocular space. Early detection, accurate staging and re‑staging, efficient monitoring of treatment response, non-invasive differentiation between benign and malignant lesions, and accurate planning of external radiation treatment, are of utmost importance for the optimal and individualized management of ophthalmic oncology patients. Addressing these challenges requires the employment of several diagnostic imaging techniques, such as high‑definition digital fundus photography, ultrasound imaging, optical coherence tomography,opticalcoherencetomography(OCT)-angiography, computed tomography (CT) and magnetic resonance imaging (MRI). In recent years, technological advances have enabled the development of hybrid positron emission tomography (PET)/CT and PET/MRI systems, setting new standards in cancer diagnosis and treatment. The capability of simultaneously targeting several cancer-related biochemical procedures using positron emitting-radiopharmaceuticals, while morphologically characterizing lesions by CT or MRI, together with the intrinsic quantitative capabilities of PET-imaging, provide incremental diagnostic information, enabling accurate, highly efficient and personalized treatment strategies. Aim of the current review is to discuss the current applications of hybrid PET/CT and PET/MRI imaging in the management of patients presenting with the most commonly encountered orbital and ocular tumors.

Original languageEnglish (US)
Pages (from-to)407-419
Number of pages13
JournalInternational journal of oncology
Issue number2
StatePublished - 2020
Externally publishedYes


  • Cancer
  • Ocular tumors
  • Orbital tumors
  • Positron emission tomography/ magnetic resonance imaging
  • Positron emission tomography/computed tomography
  • Staging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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