Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma

Shweta Choudhry, Ngim Ung, Pedro C. Avila, Elad Ziv, Sylvette Nazario, Jesus Casal, Alfonso Torres, Jennifer D. Gorman, Keyan Salari, Jose R. Rodriguez-Santana, Monica Toscano, Jody Senter Sylvia, Maria Elena Alioto, Richard A. Castro, Michael Salazar, Ivan Gomez, Joanne K. Fagan, Jorge Salas, Suzanne Clark, Craig LillyHenry Matallana, Moises Selman, Rocio Chapela, Dean Sheppard, Scott T. Weiss, Jean G. Ford, Homer A. Boushey, Jeffrey M. Drazen, William Rodriguez-Cintron, Edwin K. Silverman, Esteban González Burchard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

Background: In the United States, Puerto Ricans and Mexicans have the highest and lowest asthma prevalence, morbidity, and mortality, respectively. Ethnic-specific differences in the response to drug treatment may contribute to differences in disease outcomes. Genetic variants at the β2- adrenergic receptor (β2AR) may modify asthma severity and albuterol responsiveness. We tested the association of β2AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma. Methods: We used both family-based and cross-sectional tests of association with 8 β2AR single nucleotide polymorphisms in 684 Puerto Rican and Mexican families. Regression analyses were used to determine the interaction between genotype, asthma severity, and bronchodilator drug responsiveness. Results: Among Puerto Ricans with asthma, the arginine (Arg) 16 allele was associated with greater bronchodilator response using both family-based and cross-sectional tests (p = 0.00001-0.01). We found a strong interaction of baseline FEV1 with the Arg16Glycine (Gly) polymorphism in predicting bronchodilator response. Among Puerto Ricans with asthma with baseline FEV1 < 80% of predicted, but not in those with FEV1 > 80%, there was a very strong association between the Arg16 genotype and greater bronchodilator responsiveness. No association was observed between Arg16Gly genotypes and drug responsiveness among Mexicans with asthma. Conclusions: Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and drug responsiveness.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Volume171
Issue number6
DOIs
StatePublished - Mar 15 2005

Keywords

  • Asthma genetics
  • Latinos
  • Pharmacogenetic
  • β-adrenergic receptor gene

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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