Abstract
Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.
Original language | English (US) |
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Pages (from-to) | 364-369 |
Number of pages | 6 |
Journal | Journal of Medical Primatology |
Volume | 43 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1 2014 |
Keywords
- HIV microbicide
- Non-human primates
- Pre-exposure prophylaxis
- Sustained release
ASJC Scopus subject areas
- General Veterinary
- Animal Science and Zoology