Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan; Chuong Dinh; Jining Zhang; Chou Pong Pau; Janet M. Mcnicholl; Yungtai Lo; Betsy C. Herold; Ryan Teller; Patrick Kiser; James M. Smith

doi:10.1111/jmp.12119

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou Pong Pau, Janet M. Mcnicholl, Yungtai Lo, Betsy C. Herold, Ryan Teller, Patrick Kiser, James M. Smith^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

Original language	English (US)
Pages (from-to)	364-369
Number of pages	6
Journal	Journal of Medical Primatology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1111/jmp.12119
State	Published - Oct 1 2014

Keywords

HIV microbicide
Non-human primates
Pre-exposure prophylaxis
Sustained release

ASJC Scopus subject areas

General Veterinary
Animal Science and Zoology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/jmp.12119

Cite this

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title = "Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use",

abstract = "Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.",

keywords = "HIV microbicide, Non-human primates, Pre-exposure prophylaxis, Sustained release",

author = "Priya Srinivasan and Chuong Dinh and Jining Zhang and Pau, {Chou Pong} and Mcnicholl, {Janet M.} and Yungtai Lo and Herold, {Betsy C.} and Ryan Teller and Patrick Kiser and Smith, {James M.}",

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AU - Srinivasan, Priya

AU - Dinh, Chuong

AU - Zhang, Jining

AU - Pau, Chou Pong

AU - Mcnicholl, Janet M.

AU - Lo, Yungtai

AU - Herold, Betsy C.

AU - Teller, Ryan

AU - Kiser, Patrick

AU - Smith, James M.

PY - 2014/10/1

Y1 - 2014/10/1

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AB - Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

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KW - Non-human primates

KW - Pre-exposure prophylaxis

KW - Sustained release

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