Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan; Chuong Dinh; Jining Zhang; Chou Pong Pau; Janet M. Mcnicholl; Yungtai Lo; Betsy C. Herold; Ryan Teller; Patrick Kiser; James M. Smith

doi:10.1111/jmp.12119

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use

Priya Srinivasan, Chuong Dinh, Jining Zhang, Chou Pong Pau, Janet M. Mcnicholl, Yungtai Lo, Betsy C. Herold, Ryan Teller, Patrick Kiser, James M. Smith^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

Original language	English (US)
Pages (from-to)	364-369
Number of pages	6
Journal	Journal of Medical Primatology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1111/jmp.12119
State	Published - Oct 1 2014

Keywords

HIV microbicide
Non-human primates
Pre-exposure prophylaxis
Sustained release

ASJC Scopus subject areas

veterinary(all)
Animal Science and Zoology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/jmp.12119

Cite this

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title = "Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use",

abstract = "Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.",

keywords = "HIV microbicide, Non-human primates, Pre-exposure prophylaxis, Sustained release",

author = "Priya Srinivasan and Chuong Dinh and Jining Zhang and Pau, {Chou Pong} and Mcnicholl, {Janet M.} and Yungtai Lo and Herold, {Betsy C.} and Ryan Teller and Patrick Kiser and Smith, {James M.}",

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AU - Srinivasan, Priya

AU - Dinh, Chuong

AU - Zhang, Jining

AU - Pau, Chou Pong

AU - Mcnicholl, Janet M.

AU - Lo, Yungtai

AU - Herold, Betsy C.

AU - Teller, Ryan

AU - Kiser, Patrick

AU - Smith, James M.

PY - 2014/10/1

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AB - Background and Methods: A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions: Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.

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KW - Non-human primates

KW - Pre-exposure prophylaxis

KW - Sustained release

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