Pharmacokinetic studies of prednisolone in children. Plasma levels, half-life values, and correlation with physiologic assays for growth and immunity

Orville C. Green*, Robert J. Winter, Frank S. Kawahara, Lawrence S. Phillips, Peter R. Lewy, Robert L. Hart, Lauren M. Pachman, Paul S. Lietman

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be value in identifying those children who accumulate excessively high levels on moderate dosage regimens.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalThe Journal of pediatrics
Volume93
Issue number2
DOIs
StatePublished - Aug 1978

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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