Abstract
The concentrations of acetaminophen in human plasma were determined by RP-HPLC after administration of a single oral dose of 1000 mg acetaminophen oral drop or tablet to eight normal male volunteers in a crossover study. The concentration vs time curves of acetaminophen all fitted the two compartment model. The C(max) in oral drop and tablet were 11.23 ± 0.93 and 8.79 ± 0.93 mg/L, respectively; T(max) were 0.86 ± 0.08 and 1.48 ± 0.39 h; T( 1/2 )β 3.03 ± 0.79 and 2.51 ± 1.10 h; AUC 42.35 ± 6.20 and 40.60 ± 6.79 mg/L · h. When AUC in tablet was 100%, the relative bioavailability of acetaminophen oral drop was 105.58%. The results showed that the oral drop and tablet are bioequivalent.
Original language | English (US) |
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Pages (from-to) | 410-413 |
Number of pages | 4 |
Journal | Journal of West China University of Medical Sciences |
Volume | 25 |
Issue number | 4 |
State | Published - 1994 |
Keywords
- acetaminophen
- oral drop
- pharmacokinetics
- relative bioavailability
ASJC Scopus subject areas
- General Medicine