Pharmacokinetics of high dose thiotepa in children undergoing autologous bone marrow transplantation

Morris Kletzel*, G. L. Kearns, T. G. Wells, H. C. Thompson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Pharmacokinetics of high dose thiotepa was studied in 10 children who received this drug as a 2 h infusion at a dose of 300 mg/m2 daily for 3 days. The thiotepa was quantitated using a modification of a previously published gas chromatographic method. Samples were obtained at predetermined times post infusion. The peak plasma concentrations immediately following the infusion ranged from 5.5 to 25.2 (2.0 ± 6.6) mg/l and the 8 h post infusion ranged from 0.06 to 0.7 (0.32 ± 0.21) mg/l. The disposition of thiotepa was best described as a simple one compartment open model. The mean (± SEM) values for apparent elimination half-life (t( 1/2 β)), total plasma clearance (CL) and steady volume of distribution (VD(ss)) were 1.3 x h, 11.25 (1.73) l/h/m2 and 19.38 (2.58) l/m2 respectively. In conclusion the pharmacokinetics of high dose thiotepa in children between 2 and 12 years of age do not appear to vary from those reported in children receiving 75 mg/m2 or adults receiving similar doses.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalBone Marrow Transplantation
Volume10
Issue number2
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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