Pharmacokinetics of inhalation agents

Carly C. Guthrie, Jeffrey Lu

Research output: Chapter in Book/Report/Conference proceedingChapter


Induction speed: alveolar pressure (PA)-arterial pressure (Pa)-Pbrain, thus PA is only an approximation of Pbrain. Blood passes though the capillaries of the lungs and the anesthetic partial pressure equalizes between the alveolar and arterial pressure. Then, due to the movement of arterial blood throughout the body, and after a short period of equilibration, the alveolar partial pressure of the gas equals the brain partial pressure. Alveolar partial pressure can be increased by increasing minute ventilation, increasing flow rates at the level of the vaporizer, and by using a nonrebreathing circuit.

Original languageEnglish (US)
Title of host publicationEssential Clinical Anesthesia Review
Subtitle of host publicationKeywords, Questions and Answers for the Boards
PublisherCambridge University Press
Number of pages3
ISBN (Electronic)9781139584005
ISBN (Print)9781107681309
StatePublished - Jan 1 2015


  • Alveolar tension curve
  • Alveolar-venous partial pressure difference
  • Concentration effect
  • Diffusion hypoxia
  • Elevated cardiac output
  • Elimination
  • Induction speed
  • Intracardiac shunts
  • Meyer-Overton theory
  • Second gas effect
  • Solubility
  • VRG/VPG/fat/muscle groups

ASJC Scopus subject areas

  • Medicine(all)


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