Pharmacokinetics of prednisolone transfer to breast milk

Paul A. Greenberger*, Yaseen K. Odeh, Marilynn C. Frederiksen, Arthur J. Atkinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Prednisolone transfer to breast milk was studied in three nursing women who required oral steroid therapy for asthma. Each patient received a 50 mg intravenous dose of prednisolone phosphate, and blood and breast milk were sampled for 6 hours. Concentrations of prednisolone in milk declined more rapidly than in serum but were similar to expected unbound serum concentrations, suggesting that exchange between unbound prednisolone in serum and breast milk is relatively rapid and bidirectional. Because an average of 0.025% (range, 0.010% to 0.049%) of the prednisolone dose was recovered in milk, prednisolone transfer to breast milk does not appear to pose a clinically significant risk to nursing infants.

Original languageEnglish (US)
Pages (from-to)324-328
Number of pages5
JournalClinical pharmacology and therapeutics
Issue number3
StatePublished - Mar 1993

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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