Abstract
Nine rabbits were given s.c. doses of 7.5 mg of gentamicin/kg every 24 hr, and nine were given 2.5 mg of gentamicin/kg every 8 hr for three weeks or longer. Renal function was evaluated by monitoring of the concentration of creatinine in serum and the rate of clearance of gentamicin from serum. In the animals receiving the 8-hr divided dosage, a deterioration of renal function as early as day 7 was demonstrated by the rate of clearance of gentamicin, and deterioration by day 21 was evidenced by the concentration of creatinine in serum; the renal function of the animals receiving the single daily dose was unchanged. There was no relationship between peak or trough concentrations of gentamicin in serum and the development of nephrotoxicity. The animals receiving the 8-hr dosages had a significantly longer daily duration of exposure to concentrations of ≥0.1, ≥1.0, ≥2.0, and ≥3.0 μg of gentamicin/ml in serum than did animals receiving the daily dosage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 952-956 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 135 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1977 |
Funding
The present study was designed to explore the pharmacologic factors associated with nephro- Received for publication June 2, 1976, and in revised form November 18, 1976. This paper was presented in part at the American Federation for Clinical Research, Midwest Section Meeting, November 3, 1973 in Chicago, Illinois. This study was supported by the Morton Hamburger Memorial Fund, by a grant from the Schering Corporation, and by a Merrell Clinical Research Fellowship granted to Dr. Frame. Please address requests for reprints to Dr. P. T. Frame, Infectious Disease Division, 7th Floor, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267.
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
