Pharmacologic factors associated with gentamicin nephrotoxicity in rabbits

P. T. Frame, J. P. Phair, C. Watanakunakorn, T. W.P. Bannister

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63 Scopus citations

Abstract

Nine rabbits were given s.c. doses of 7.5 mg of gentamicin/kg every 24 hr, and nine were given 2.5 mg of gentamicin/kg every 8 hr for three weeks or longer. Renal function was evaluated by monitoring of the concentration of creatinine in serum and the rate of clearance of gentamicin from serum. In the animals receiving the 8-hr divided dosage, a deterioration of renal function as early as day 7 was demonstrated by the rate of clearance of gentamicin, and deterioration by day 21 was evidenced by the concentration of creatinine in serum; the renal function of the animals receiving the single daily dose was unchanged. There was no relationship between peak or trough concentrations of gentamicin in serum and the development of nephrotoxicity. The animals receiving the 8-hr dosages had a significantly longer daily duration of exposure to concentrations of ≥0.1, ≥1.0, ≥2.0, and ≥3.0 μg of gentamicin/ml in serum than did animals receiving the daily dosage.

Original languageEnglish (US)
Pages (from-to)952-956
Number of pages5
JournalJournal of Infectious Diseases
Volume135
Issue number6
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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