Pharmacologic modulation of ACE2 expression

María José Soler, Clara Barrios, Raymond Oliva, Daniel Batlle*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.

Original languageEnglish (US)
Article number410
Pages (from-to)410-414
Number of pages5
JournalCurrent hypertension reports
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2008

Keywords

  • ACE2 Activity
  • ACE2 Protein
  • Eplerenone
  • Olmesartan
  • Telmisartan

ASJC Scopus subject areas

  • Internal Medicine

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