Pharmacologic modulation of ACE2 expression

María José Soler; Clara Barrios; Raymond Oliva; Daniel Batlle

doi:10.1007/s11906-008-0076-0

Pharmacologic modulation of ACE2 expression

María José Soler, Clara Barrios, Raymond Oliva, Daniel Batlle^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.

Original language	English (US)
Article number	410
Pages (from-to)	410-414
Number of pages	5
Journal	Current hypertension reports
Volume	10
Issue number	5
DOIs	https://doi.org/10.1007/s11906-008-0076-0
State	Published - Oct 1 2008

Keywords

ACE2 Activity
ACE2 Protein
Eplerenone
Olmesartan
Telmisartan

ASJC Scopus subject areas

Internal Medicine

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10.1007/s11906-008-0076-0

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AB - Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.

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KW - Olmesartan

KW - Telmisartan

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Pharmacologic modulation of ACE2 expression

Abstract

Keywords

ASJC Scopus subject areas

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