PHarmacologic therapy of pseudophakic cystoid macular edema: 2010 update

Heather N. Shelsta, Lee M. Jampol

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


Purpose: To review the current management and pharmacologic treatment of pseudophakic cystoid macular edema. Methods: Systematic review of currently accepted treatment modalities for pseudophakic cystoid macular edema. Main outcome measures include visual acuity and retinal thickness measurement by optical coherence tomography. Results: Optical coherence tomography is used to diagnose and monitor response to therapy. New topical nonsteroidal antiinflammatory drugs have been approved by the Food and Drug Administration for ophthalmic use, and some show promise in the treatment of pseudophakic cystoid macular edema. Other areas of clinical research include the use of anti-vascular endothelial growth factor agents and the addition of intravitreal routes of administration (e.g., corticosteroids, nonsteroidal antiinflammatory drugs, and anti-vascular endothelial growth factor agents). Surgical therapeutic options include Nd:YAG laser for anterior vitreolysis and pars plana vitrectomy for chronic refractory cases. Conclusion: Surprisingly, few changes have occurred in recent years in the treatment of pseudophakic cystoid macular edema. Placebo-controlled, double-masked, randomized, clinical trials are largely lacking.

Original languageEnglish (US)
Pages (from-to)4-12
Number of pages9
Issue number1
StatePublished - Jan 1 2011


  • anti-vascular endothelial growth factor
  • carbonic anhydrase inhibitors
  • corticosteroids
  • nonsteroidal antiinflammatory drugs
  • optical coherence tomography
  • pseudophakic cystoid macular edema

ASJC Scopus subject areas

  • Ophthalmology


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